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| | Axin1 (C95H11) Rabbit mAb Chemical Properties |
| | Axin1 (C95H11) Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Monkey | | Background | Axin1 and Axin2 are multidomain scaffold proteins that negatively regulate Wnt signaling. Axin1 interacts with APC, GSK-3β, Dvl, and β-catenin and promotes the GSK-3β-mediated phosphorylation and subsequent degradation of β-catenin. Upon stimulation of cells with Wnt, Axin1 is recruited to the membrane by phosphorylated LRP5/6, a process that is believed to be crucial for activation of Wnt signaling. In addition to its role in the Wnt signaling pathway, Axin1 forms a complex with MEKK1 and activates c-Jun amino-terminal kinase. Axin2 can functionally substitute for Axin1 in mice. Axin2 itself is a direct target of the Wnt signaling pathway and therefore serves to control the duration and/or intensity of Wnt signaling through a negative feedback loop. | | References | [1] Luo, W. and Lin, S.C. Neurosignals 13, 99-113.
[2] Salahshor, S. and Woodgett, J.R. (2005) J. Clin. Pathol. 58, 225-236.
[3] Zeng, X. et al. (2005) Nature 438, 873-877.
[4] Davidson, G. et al. (2005) Nature 438, 867-872.
[5] Zhang, Y. et al. (1999) J. Biol. Chem. 274, 35247-35254.
[6] Chia, I.V. and Costantini, F. (2005) Mol. Cell Biol. 25, 4371-4376.
[7] Jho, E.H. et al. (2002) Mol. Cell Biol. 22, 1172-1183.
[8] Lustig, B. et al. (2002) Mol. Cell Biol. 22, 1184-1193.
[9] Leung, J.Y. et al. (2002) J. Biol. Chem. 277, 21657-21665. |
| | Axin1 (C95H11) Rabbit mAb Preparation Products And Raw materials |
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