| Company Name: |
Fedprotein |
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13041401126; 13041401126 |
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3690410801@qq.com |
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| Product Name: | CD177 antibody | | Synonyms: | CD177 antibody;Mouse Monoclonal CD177 Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![CD177 antibody Structure]() |
| | CD177 antibody Chemical Properties |
| | CD177 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Mouse | | Background | Cluster of differentiation 177 antigen, is a glycosyl-phosphatidylinositol-linked N-glycosylated transmembrane protein expressed primarily on the surface of neutrophils. Expression of CD177 can be induced by granulocyte-colony-stimulating factor and during pregnancy or bacterial infection. CD177 mediates adhesion and transendothelial migration of neutrophils via interaction with CD31/PECAM-1 and integrin β2 on endothelial cells. CD177 also promotes the cell surface expression of proteinase 3, which may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis. In association with CD11b/ITGAM, integrin β2, and PR3, CD177 promotes activation of TNF-α primed neutrophils including degranulation and superoxide production. CD177 is a polymorphic gene that has been linked to several important clinical diseases, including polycythemia vera, Wegener’s granulomatosis, and immune mediated neonatal neutropenia. | | References | [1] Matsuo, K. et al. (2000) Transfusion 40, 654-62.
[2] Xie, Q. et al. (2015) Protein Cell 6, 117-26.
[3] Stroncek, D.F. et al. (1998) Transfusion 38, 663-8.
[4] Caruccio, L. et al. (2003) Transfusion 43, 357-63.
[5] Göhring, K. et al. (2004) Br J Haematol 126, 252-4.
[6] Sachs, U.J. et al. (2007) J Biol Chem 282, 23603-12.
[7] Bai, M. et al. (2017) Blood 130, 2092-100.
[8] von Vietinghoff, S. et al. (2007) Blood 109, 4487-93.
[9] von Vietinghoff, S. et al. (2008) Clin Exp Immunol 152, 508-16.
[10] Kuckleburg, C.J. and Newman, P.J. (2013) Arterioscler Thromb Vasc Biol 33, 275-84.
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| | CD177 antibody Preparation Products And Raw materials |
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