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| | DIS3 antibody Chemical Properties |
| | DIS3 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey | | Background | DIS3, also known as RRP44, is a conserved protein responsible for the core catalytic activities of the exosome complex, which degrades RNA. With two catalytic sites, DIS3 possesses both endoribonucleolytic and 3’-to-5’ exoribonucleolytic activity. It plays very diverse roles in RNA metabolism, including control of aberrant pre-mRNA turnover, gene expression, and RNA processing. DIS3 also plays a role in mitotic progression by helping form kinetochores. Additionally, DIS3 is implicated in antibody diversity by helping the exosome target activation-induced cytidine deaminase to the DNA strands in B cells. DIS3 and other exosome components are upregulated during V(D)J recombination and B cells in knockout mice are unable to develop past the pro-B cell stage. Mutations in the DIS3 gene have been well described in multiple myeloma. | | References | [1] Vincent, H.A. and Deutscher, M.P. (2006) J Biol Chem 281, 29769-75.
[2] Dziembowski, A. et al. (2007) Nat Struct Mol Biol 14, 15-22.
[3] Liu, Q. et al. (2006) Cell 127, 1223-37.
[4] Lebreton, A. et al. (2008) Nature 456, 993-6.
[5] Bousquet-Antonelli, C. et al. (2000) Cell 102, 765-75.
[6] Milligan, L. et al. (2005) Mol Cell Biol 25, 9996-10004.
[7] Mukherjee, D. et al. (2002) EMBO J 21, 165-74.
[8] Allmang, C. et al. (1999) EMBO J 18, 5399-410.
[9] Murakami, H. et al. (2007) PLoS One 2, e317.
[10] Kinoshita, N. et al. (1991) Mol Cell Biol 11, 5839-47.
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| | DIS3 antibody Preparation Products And Raw materials |
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