| Company Name: |
Hubei Ipodix Biotechnology Co.,Ltd.
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| Tel: |
18007124176 19384116026 |
| Email: |
2706668885@qq.com |
| Products Intro: |
Product Name:GPAT4 antibody
Purity:99% Package:50ul/RMB 1280;100ul/RMB 2180
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| Company Name: |
Hubei Serenity BioSolutions Co., Ltd.
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| Tel: |
027-19371278702 18008634902 |
| Email: |
19384116026@163.com |
| Products Intro: |
Product Name:Rabbit Polyclonal GPAT4 Antibody
Package:20μl;50μl;100μl
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| Product Name: | GPAT4 antibody | | Synonyms: | GPAT4 antibody;Rabbit Polyclonal GPAT4 Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![GPAT4 antibody Structure]() |
| | GPAT4 antibody Chemical Properties |
| | GPAT4 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human | | Background | Glycerol-3-phosphate acyltransferases catalyze the first step in the de novo synthesis of triacylglycerol and phospholipids by converting glycerol-3-phosphate to lysophosphatidic acid. The GPAT family consists of four family members: two mitochondrial proteins and two microsomal proteins. Each can differ in tissue expression, regulation, and physiological and pathophysiological roles. The microsomal proteins GPAT3 and GPAT4 were originally designated as AGPAT8 and AGPAT6, respectively. 1-acyl-glycerol-3-phosphate acyltransferase catalyzes the subsequent reaction converting LPA to phosphatidic acid. The genes were renamed to GPAT3 and GPAT4 upon elucidation of GPAT activity. Both GPAT3 and GPAT4 are expressed in adipose tissue, but GPAT3 is highly induced during adipocyte differentiation. Brown adipose tissue preferentially expresses GPAT4. GPAT3 and GPAT4 may also be phosphorylated in response to insulin treatment to increase GPAT activity. Accumulation of saturated LPA produced by GPAT4 at the ER-mitochondrial contact site can inhibit autophagy through the abnormal formation of omegasomes, which are precursors to the autophagosome. Glycerolipid synthesis by GPAT3 and GPAT4 can also regulate activation of macrophages. | | References | [1] Yamashita, A. et al. (2014) Biology (Basel) 3, 801-30.
[2] Karasawa, K. et al. (2019) Int J Mol Sci 20, 964. doi: 10.3390/ijms20040964.
[3] Chen, Y.Q. et al. (2008) J Biol Chem 283, 10048-57.
[4] Cao, J. et al. (2006) Proc Natl Acad Sci U S A 103, 19695-700.
[5] Cooper, D.E. et al. (2015) J Biol Chem 290, 15112-20.
[6] Shan, D. et al. (2010) J Lipid Res 51, 1971-81.
[7] Shiozaki, Y. et al. (2020) iScience 23, 101105.
[8] Quiroga, I.Y. et al. (2019) Biochem J 476, 85-99. |
| | GPAT4 antibody Preparation Products And Raw materials |
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