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| Product Name: | GPI antibody | | Synonyms: | GPI antibody;Rabbit Polyclonal GPI Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![GPI antibody Structure]() |
| | GPI antibody Chemical Properties |
| | GPI antibody Usage And Synthesis |
| Source | Rabbit | | Applications | The antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity. | | Reactivity | Human;Monkey | | Immunogen | Anti-human GPI mAb, clone PAT22G2AT, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human GPI protein 1-558 amino acids purified from E. coli.
| | Background | Glucose-6-phosphate isomerase (GPI) is a part of the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. GPI is a dimeric enzyme which catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. Mammalian GPI also functions as a tumor-secreted cytokine and an angiogenic factor (AMF) which stimulates endothelial cell motility. In addition, GPI is a neurotrophic factor (Neuroleukin) for spinal and sensory neurons. GPI performs in different capacities inside and outside the cell. In the cytoplasm, GPI is involved in glycolysis and gluconeogenesis, while outside the cell it acts as a neurotrophic factor for spinal and sensory neurons.
Defects in the GPI gene cause the nonspherocytic hemolytic anemia and a severe enzyme deficiency can be linked to hydrops fetalis, immediate neonatal death and neurological impairment.
| | References | [1] Haga, A. et al. (2000) Biochim Biophys Acta 1480, 235-44.
[2] Jeffery, C.J. et al. (2000) Biochemistry 39, 955-64.
[3] Kim, J.W. and Dang, C.V. (2005) Trends Biochem Sci 30, 142-150.
[4] Fairbank, M. et al. (2009) Mol Biosyst 5, 793-801.
[5] Gurney, M.E. et al. (1986) Science 234, 574-81.
[6] Gurney, M.E. et al. (1986) Science 234, 566-74.
[7] Lucarelli, G. et al. (2015) Medicine (Baltimore) 94, e2117.
[8] Liotta, L.A. et al. (1986) Proc Natl Acad Sci U S A 83, 3302-6.
[9] Funasaka, T. and Raz, A. (2007) Cancer Metastasis Rev 26, 725-35. |
| | GPI antibody Preparation Products And Raw materials |
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