|
|
| | HSP27 (G31) Mouse mAb Chemical Properties |
| | HSP27 (G31) Mouse mAb Usage And Synthesis |
| Source | Mouse | | Reactivity | Human;Monkey | | Background | Heat shock protein 27 is one of the small HSPs that are constitutively expressed at different levels in various cell types and tissues. Like other small HSPs, HSP27 is regulated at both the transcriptional and posttranslational levels. In response to stress, the HSP27 expression increases several-fold to confer cellular resistance to the adverse environmental change. HSP27 is phosphorylated at Ser15, Ser78, and Ser82 by MAPKAPK-2 as a result of the activation of the p38 MAP kinase pathway. Phosphorylation of HSP27 causes a change in its tertiary structure, which shifts from large homotypic multimers to dimers and monomers. It has been shown that phosphorylation and increased concentration of HSP27 modulates actin polymerization and reorganization. | | References | [1] Stetler, R.A. et al. (2009) Curr Mol Med 9, 863-72.
[2] Landry, J. et al. (1992) J Biol Chem 267, 794-803.
[3] Rouse, J. et al. (1994) Cell 78, 1027-37.
[4] Rogalla, T. et al. (1999) J Biol Chem 274, 18947-56.
[5] Lavoie, J.N. et al. (1993) J Biol Chem 268, 24210-4.
[6] Rousseau, S. et al. (1997) Oncogene 15, 2169-77. |
| | HSP27 (G31) Mouse mAb Preparation Products And Raw materials |
|