| Company Name: |
CUSABIO TECHNOLOGY LLC
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| Tel: |
027-87196173 |
| Email: |
cusabio@163.com |
| Products Intro: |
Product Name:LAMC1 Antibody
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| Company Name: |
Shanghai Qierqi Biotech Co., Ltd
|
| Tel: |
027-19371278702 18008634902 |
| Email: |
nuodina88@163.com |
| Products Intro: |
Product Name:Rabbit Polyclonal LAMC1 Antibody
Package:20μl;50μl;100μl
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| Company Name: |
Enzo Biochem Inc
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| Tel: |
Enzo Biochem Inc. 13797054060 |
| Email: |
Enzoname@qq.com |
| Products Intro: |
Product Name:LAMC1 Antibody
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| Company Name: |
Biosynth Ltd
|
| Tel: |
18886812933 |
| Email: |
sales@biosynth.com |
| Products Intro: |
Product Name:LAMC1 antibody
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| Product Name: | LAMC1 antibody | | Synonyms: | LAMC1 antibody;Rabbit Polyclonal LAMC1 Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![LAMC1 antibody Structure]() |
| | LAMC1 antibody Chemical Properties |
| | LAMC1 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat | | Background | Laminins are a family of proteins important for maintaining cellular basement membrane structure and function. Laminins exist as heterotrimers of alpha, beta, and gamma chains. LAMC1 is a ubiquitously expressed gamma chain, and has three distinct functional domain structures. The N-terminal LN domain binds to specific alpha and beta chains to form a unique laminin heterotrimer. The LE domain mediates interactions with nidogens, while the C-terminal coil-coil fragment is necessary for agrin association. Collectively, these interactions are critical for stabilization and function of the BM. Genetic ablation of LAMC1 has demonstrated a critical role for this protein in embryo implantation, lung and kidney development, and neuronal Schwann cell myelination and regeneration, in addition to Trypanosome infection. Upregulation of LAMC1 has also been associated with tumor progression in multiple tumor types, possibly by creating a BM environment that is favorable for cancer cell metastasis and invasion. | | References | [1] Yurchenco, P.D. (2011) Cold Spring Harb Perspect Biol 3, a004911.
[2] Ramathal, C. et al. (2011) J Biol Chem 286, 19860-71.
[3] Willem, M. et al. (2002) Development 129, 2711-22.
[4] Chen, Z.L. and Strickland, S. (2003) J Cell Biol 163, 889-99.
[5] Nde, P.N. et al. (2012) Front Immunol 3, 337.
[6] Liétard, J. et al. (1997) Am J Pathol 151, 1663-1672.
[7] Nishikawa, R. et al. (2014) Int J Oncol 45, 401-410.
[8] Huang, S.X. et al. (2016) Int J Oncol 49, 217-224.
[9] Kashima, H. et al. (2015) Gynecol Oncol 139, 338-344. |
| | LAMC1 antibody Preparation Products And Raw materials |
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