| Company Name: |
Hubei Ipodix Biotechnology Co.,Ltd.
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| Tel: |
18007124176 19384116026 |
| Email: |
2706668885@qq.com |
| Products Intro: |
Product Name:LYN antibody
Purity:99% Package:50ul/RMB 1280;100ul/RMB 2180
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| Company Name: |
Novus Biologicals
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| Tel: |
400821347 |
| Email: |
orders@novusbio.com |
| Products Intro: |
Product Name:Lyn Antibody
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| Company Name: |
CUSABIO TECHNOLOGY LLC
|
| Tel: |
027-87196173 |
| Email: |
cusabio@163.com |
| Products Intro: |
Product Name:LYN Antibody
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| Company Name: |
GeneTex, Inc.
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| Tel: |
0755-26755892 1-949-553-1900 |
| Email: |
international@genetex.com |
| Products Intro: |
Product Name:LYN antibody
|
| Company Name: |
NSJ Bioreagents
|
| Tel: |
858.663.9055 8586639055 |
| Email: |
NSJBioname@qq.com |
| Products Intro: |
Product Name:LYN Antibody
|
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| Product Name: | LYN antibody | | Synonyms: | LYN antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![LYN antibody Structure]() |
| | LYN antibody Chemical Properties |
| | LYN antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat | | Background | Lyn, one of the Src family members, is predominantly expressed in hematopoietic cells. Two tyrosine residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family. Autophosphorylation of Tyr396, located in the catalytic domain, correlates with enzyme activation. Csk-mediated phosphorylation of the carboxy-terminal Tyr507 inactivates the kinase. Tyrosine phosphorylation and activation of Lyn occurs upon association with cell surface receptors such as the B cell Ag receptor and CD40. Studies using knockout mice have shown that the net effect of Lyn deficiency is to render B cells hypersensitive to BCR stimulation, suggesting that the most critical role for Lyn in vivo is in the down-regulation of B cell responses. Lyn is also involved in controlling the migration and development of specific B cell populations. | | References | [1] Yamanashi, Y. et al. (1989) Proc. Natl. Acad. Sci. USA 86, 6538-6542.
[2] Yamanashi, Y. et al. (1991) Science 251, 192-194.
[3] Burkhardt, A.L. et al. (1991) Proc. Natl. Acad. Sci. USA 88, 7410-7414.
[4] Ren, C.L. et al. (1994) J. Exp. Med. 179, 673-680.
[5] Wang, J. et al. (1996) J Exp Med 184, 831-8.
[6] Chan, V.W. et al. (1997) Immunity 7, 69-81.
[7] Hibbs, M.L. et al. (1995) Cell 83, 301-11.
[8] Seo, S. et al. (2001) J Immunol 166, 3710-6. |
| | LYN antibody Preparation Products And Raw materials |
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