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| | OX40L (D6X2D) Rabbit mAb Chemical Properties |
| | OX40L (D6X2D) Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human | | Background | OX40 is a member of the tumor necrosis factor receptor superfamily that regulates T cell activity and immune responses. The OX40 protein contains four cysteine rich domains, a transmembrane domain, and a cytoplasmic tail containing a QEE motif. OX40 is primarily expressed on activated CD4+ and CD8+ T-cells, while the OX40 ligand is predominantly expressed on activated antigen presenting cells. The engagement of OX40 with OX40L leads to the recruitment of TNF receptor-associated factors and results in the formation of a TCR-independent signaling complex. One component of this complex, PKCθ, activates the NF-κB pathway. OX40 signaling through Akt can also enhance TCR signaling directly. Research studies indicate that the OX40L-OX40 pathway is associated with inflammation and autoimmune diseases. Additional research studies show that OX40 agonists augment anti-tumor immunity in several cancer types. | | References | [1] Croft, M. (2010) Annu Rev Immunol 28, 57-78.
[2] So, T. and Croft, M. (2012) Front Immunol 3, 133.
[3] Paterson, D.J. et al. (1987) Mol Immunol 24, 1281-90.
[4] Mallett, S. et al. (1990) EMBO J 9, 1063-8.
[5] Dürkop, H. et al. (1995) Br J Haematol 91, 927-31.
[6] Godfrey, W.R. et al. (1994) J Exp Med 180, 757-62.
[7] Al-Shamkhani, A. et al. (1997) J Biol Chem 272, 5275-82.
[8] So, T. et al. (2011) Proc Natl Acad Sci U S A 108, 2903-8.
[9] So, T. and Croft, M. (2013) Front Immunol 4, 139.
[10] Gough, M.J. and Weinberg, A.D. (2009) Adv Exp Med Biol 647, 94-107.
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| | OX40L (D6X2D) Rabbit mAb Preparation Products And Raw materials |
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