| Company Name: |
BOC Sciences |
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16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
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| Product Name: | E67-2 | | Synonyms: | E67-2;2,4-Quinazolinediamine, 7-[(5-aminopentyl)oxy]-N2-[3-(dimethylamino)propyl]-6-methoxy-N4,N4-dimethyl- | | CAS: | 1364914-62-4 | | MF: | C21H36N6O2 | | MW: | 404.55 | | EINECS: | | | Product Categories: | | | Mol File: | 1364914-62-4.mol |  |
| | E67-2 Chemical Properties |
| | E67-2 Usage And Synthesis |
| Uses | E67-2, as the E67 derivative, is a low-toxicity, selective KIAA1718 Jumonji domain inhibitor with an IC50 value of 3.4 μM. E67-2 selectively inhibits histone H3 lysine 9 (H3K9) Jumonji demethylase as well as histone H3 lysine 4 (H3K4) demethylase[1]. | | References | [1] Upadhyay AK, et al. An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases. J Mol Biol. 2012;416(3):319-327. DOI:10.1016/j.jmb.2011.12.036 |
| | E67-2 Preparation Products And Raw materials |
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