QM31 manufacturers
- QM31
-
- $1520.00
-
2026-07-27
- CAS:937735-00-7
- Purity:
- Supply Ability: 10g
- QM31
-
- $1520.00
-
2026-07-27
- CAS:937735-00-7
- Purity:
- Supply Ability: 10g
- QM31
-
- $1520.00
-
2025-10-28
- CAS:937735-00-7
- Purity:
- Supply Ability: 10g
|
| Product Name: | QM31 | | Synonyms: | QM31;SVT016426;1H-1,4-Diazepine-5-carboxamide, N-(2-amino-2-oxoethyl)-N,1-bis[2-(2,4-dichlorophenyl)ethyl]-4-(3,3-diphenylpropyl)hexahydro-3,7-dioxo-;QM31,QM-31 | | CAS: | 937735-00-7 | | MF: | C39H38Cl4N4O4 | | MW: | 768.56 | | EINECS: | | | Product Categories: | | | Mol File: | 937735-00-7.mol |  |
| Boiling point | 960.8±65.0 °C(Predicted) | | density | 1.340±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 15.47±0.40(Predicted) | | form | Solid | | color | White to off-white |
| Uses | QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint[1][2]. | | References | [1] Mondragón L, et al. A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. Apoptosis. 2009 Feb;14(2):182-90. DOI:10.1007/s10495-008-0310-x
[2] Orzáez M, et al. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. PLoS One. 2014 Oct 20;9(10):e110979. DOI:10.1371/journal.pone.0110979
[3] Gortat A, et al. Apaf1 inhibition promotes cell recovery from apoptosis. Protein Cell. 2015 Nov;6(11):833-43. DOI:10.1007/s13238-015-0200-2 |
| | QM31 Preparation Products And Raw materials |
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