Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-

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Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)- manufacturers

  • NV-5138
  • NV-5138 pictures
  • $91.00
  • 2026-07-27
  • CAS:2095886-80-7
  • Purity: 98.00%
  • Supply Ability: 10g
  • NV-5138
  • NV-5138 pictures
  • $91.00
  • 2026-07-27
  • CAS:2095886-80-7
  • Purity: 98.00%
  • Supply Ability: 10g
Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)- Basic information
Product Name:Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-
Synonyms:Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-;(2S)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid;inhibit,Inhibitor,NV-5138,mTOR,NV5138,Mammalian target of Rapamycin,NV 5138;NV-5138, 10 mM in DMSO;NV-5138
CAS:2095886-80-7
MF:C7H13F2NO2
MW:181.18
EINECS:
Product Categories:
Mol File:2095886-80-7.mol
Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)- Structure
Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)- Chemical Properties
storage temp. Store at -20°C,unstable in solution, ready to use.
solubility DMSO: 10mM
form A solid
color White to off-white
InChIInChI=1S/C7H13F2NO2/c1-7(2,6(8)9)3-4(10)5(11)12/h4,6H,3,10H2,1-2H3,(H,11,12)/t4-/m0/s1
InChIKeyHRFIMCJTDKEPPV-BYPYZUCNSA-N
SMILESC(O)(=O)[C@@H](N)CC(C)(C)C(F)F
Safety Information
MSDS Information
Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)- Usage And Synthesis
UsesNV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 is used for antidepressant studies[1][2].
in vivo

NV-5138 is found to be essentially 100% orally bioavailable with an elimination half-life in plasma of ~ 3 h determined following intravenous and oral dosing in rats[1].
NV-5138 (160 mg/kg, po, single dose) rapidly increases levels of phospho-mTOR as well as the downstream targets, phospho-p70S6K1, and phosphor-4EB-P1, in synaptosomal preparations of PFC[2].
NV-5138 (80 mg/kg, po, daily for a total of 7 days) also produces antidepressant effects[2].

Animal Model:Male Sprague-Dawley rats weighing 250-260 g[2].
Dosage:40, 80, 160 mg/kg.
Administration:PO, single dose (160 mg/kg) or daily for a total of 7 days (40, 80 mg/kg).
Result:Produced antidepressant effects.
Animal Model:Male Sprague–Dawley (SD) rats weighed 250-400 g[1].
Dosage:1 mg/kg, 5 mg/kg (Pharmacokinetic Design).
Administration:I.V at 1 mg/kg and PO at 5 mg/kg.
Result:Essentially 100% orally bioavailable with an elimination half-life in plasma of ~ 3 h.
References[1] Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9(1):4107. DOI:10.1038/s41598-019-40693-5
[2] Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554. DOI:10.1172/JCI126859
Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)- Preparation Products And Raw materials
Tag:Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-(2095886-80-7) Related Product Information
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