| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:15-keto Prostaglandin E2-d9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
CHINA ISOTOPE CO., LIMITED
|
| Tel: |
02151600108 13062666369 |
| Email: |
info@isotopechem.com |
| Products Intro: |
Product Name:15-keto Prostaglandin E2-d9
CAS:2738376-66-2
Purity:Purity: >=98% Package:100ug Remarks:CA19350
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:15-keto Prostaglandin E2-d9
CAS:2738376-66-2
Purity:95% Package:50μg;100μg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:15-keto Prostaglandin E2-d9
|
| Company Name: |
Neobioscience Co., Ltd.
|
| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:15-keto Prostaglandin E2-d9
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| | 15-keto Prostaglandin E2-d9 Basic information |
| | 15-keto Prostaglandin E2-d9 Chemical Properties |
| solubility | DMF: 50 mg/ml
DMSO: 50 mg/ml
Ethanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml |
| | 15-keto Prostaglandin E2-d9 Usage And Synthesis |
| Description | 15-keto Prostaglandin E2-d9 (15-keto PGE2-d9) is intended for use as an internal standard for the quantification of 15-keto PGE2 (Item No. 14720) by GC- or LC-MS. 15-keto PGE2 is a metabolite of PGE2 (Item No. 14010) formed by 15-hydroxy prostaglandin dehydrogenase (15-PGDH).1 Unlike PGE2, 15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 2.6 and 15 µM, respectively) or induce adenylate cyclase activity in the same cells (EC50s = 1.8 and >33 µM, respectively). However, it does bind to EP2 and EP4 in HEK cells expressing these receptors (IC50s = 0.117 and 2.82 µM, respectively), as well as induces cAMP formation (EC50s = 0.137 and 0.426 µM, respectively) and the transcriptional activity of β-catenin/TCF in the same cells.2 15-keto PGE2 inhibits CD3-CD28-MHC-I-induced proliferation of isolated human CD4+ T cells in a concentration-dependent manner.3 It also reduces mortality in a mouse model of LPS-induced sepsis when administered at a dose of 15 mg/kg.4 a Kd = 1 nM for PGE2).1WARNING This product is not for human or veterinary use. | | References | [1] N. NISHIGAKI A I M Negishi. Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist.[J]. Molecular Pharmacology, 1996, 146 1: 1031-1037. DOI: 10.1254/fpj.108.supplement_65
[2] SUZU ENDO. 15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling.[J]. The Journal of Biological Chemistry, 2020: 13338-13352. DOI: 10.1074/jbc.ra120.013988
[3] LISA SCHMIDLEITHNER. Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.[J]. Immunity, 2019: 1232-1248.e14. DOI: 10.1016/j.immuni.2019.03.014
[4] ING-JUNG CHEN . Targeting the 15-keto-PGE2-PTGR2 axis modulates systemic inflammation and survival in experimental sepsis[J]. Free Radical Biology and Medicine, 2018, 115: Pages 113-126. DOI: 10.1016/j.freeradbiomed.2017.11.016 |
| | 15-keto Prostaglandin E2-d9 Preparation Products And Raw materials |
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