| Company Name: |
Shanghai Universal Biotech Co.,Ltd
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| Tel: |
15921930842 15921930842 |
| Email: |
yh-wang@univ-bio.com |
| Products Intro: |
Product Name:CMTM6 Antibody
Package:100ul Remarks: 见优宁维官网
|
| Company Name: |
Hubei Ipodix Biotechnology Co.,Ltd.
|
| Tel: |
18007124176 19384116026 |
| Email: |
2706668885@qq.com |
| Products Intro: |
Product Name:CMTM6 antibody
Purity:99% Package:50ul/RMB 1280;100ul/RMB 2180
|
| Company Name: |
Shanghai Qierqi Biotech Co., Ltd.
|
| Tel: |
027-19371278702 18008634902 |
| Email: |
ruihening88@163.com |
| Products Intro: |
Product Name:Rabbit Polyclonal CMTM6 Antibody
Package:20μl;50μl;100μl
|
| Company Name: |
Biosynth Ltd
|
| Tel: |
18886812933 |
| Email: |
sales@biosynth.com |
| Products Intro: |
Product Name:CMTM6 antibody
|
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| | CMTM6 antibody Chemical Properties |
| | CMTM6 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse | | Background | CKLF-like MARVEL transmembrane domain-containing protein 6 is a member of the chemokine-like factor-like MARVEL transmembrane domain-containing family. CMTM6 stabilizes plasma membrane expression of PD-L1, an immune inhibitory ligand critical for immune tolerance to self and anti-tumor immunity. CMTM6 associates with PD-L1 at recycling endosomes, where it protects PD-L1 from being targeted for lysosomal degradation by preventing STUB1-mediated PD-L1 ubiquitination. CMTM6 may stabilize PD-L1 expression on antigen presenting cells and potentiate inhibitory signaling by PD-1 on T cells, triggering T cell inhibition and exhaustion. CMTM6 has also been shown to interact with CD58, ARG1, ENO1, and TMPO. Due to the role of CMTM6 in regulating the immune system, it is being investigated as an immunotherapeutic target for the treatment of cancer. | | References | [1] Han, W. et al. (2003) Genomics 81, 609-17.
[2] Burr, M.L. et al. (2017) Nature 549, 101-5.
[3] Mezzadra, R. et al. (2017) Nature 549, 106-10. |
| | CMTM6 antibody Preparation Products And Raw materials |
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