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3-BROMO-4-CHLORO-5-NITROPYRIDINE

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Products Intro: Product Name:3-Bromo-4-chloro-5-nitropyridine
CAS:31872-63-6
Purity:98%(Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg
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Products Intro: Product Name:3-BROMO-4-CHLORO-5-NITROPYRIDINE
CAS:31872-63-6
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Products Intro: Product Name:3-bromo-4-chloro-5-nitropyridine
CAS:31872-63-6
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Products Intro: Product Name:3-BROMO-4-CHLORO-5-NITROPYRIDINE
CAS:31872-63-6

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3-BROMO-4-CHLORO-5-NITROPYRIDINE Basic information
Application
Product Name:3-BROMO-4-CHLORO-5-NITROPYRIDINE
Synonyms:3-BROMO-4-CHLORO-5-NITROPYRIDINE;Pyridine, 3-broMo-4-chloro-5-nitro-;3-Nitro-4-chloro-5-bromopyridine;3-BroMo-4-chloro-5-nitropyridine HCl;3-BROMO-4-CHLORO-5-NITROPYRIDINE ISO 9001：2015 REACH;4-Chloro-5-Bromo-3-Nitropyridine
CAS:31872-63-6
MF:C5H2BrClN2O2
MW:237.44
EINECS:
Product Categories:Heterocycle-Pyridine series;Boronic Acid;Pyridine Series;Pyridine
Mol File:31872-63-6.mol
3-BROMO-4-CHLORO-5-NITROPYRIDINE Structure
3-BROMO-4-CHLORO-5-NITROPYRIDINE Chemical Properties
Melting point 49-50℃
Boiling point 285℃
density 1.936
Fp 126℃
storage temp. Inert atmosphere,Store in freezer, under -20°C
pka-0.88±0.10(Predicted)
form solid
color Light yellow
InChIInChI=1S/C5H2BrClN2O2/c6-3-1-8-2-4(5(3)7)9(10)11/h1-2H
InChIKeyFTQGEZJTBYMEIH-UHFFFAOYSA-N
SMILESC1=NC=C([N+]([O-])=O)C(Cl)=C1Br
Safety Information
RIDADR UN2811
HazardClass IRRITANT
HS Code 2933399990
MSDS Information
3-BROMO-4-CHLORO-5-NITROPYRIDINE Usage And Synthesis
Application3-Bromo-4-chloro-5-nitropyridine can be used as an organic synthesis intermediate and a pharmaceutical intermediate in laboratory research and development processes and in the synthesis of pharmaceutical chemicals.
Synthesis
3-Bromo-4-hydroxy-5-nitropyridine

31872-65-8

3-BROMO-4-CHLORO-5-NITROPYRIDINE

31872-63-6

Step 2. Synthesis of 3-bromo-4-chloro-5-nitropyridine The product of Step 1, 3-bromo-4-hydroxy-5-nitropyridine (6.57 g, 30 mmol), was slowly added to phosphoryl chloride (50 mL) under ice bath cooling conditions. Subsequently, N,N-diethylaniline (4.77 mL, 30 mmol) was added dropwise to the stirring reaction mixture. The reaction mixture was gradually warmed to room temperature and then heated to reflux for 2 hours. After completion of the reaction, the mixture was concentrated under reduced pressure and the residue was carefully poured into ice water. The aqueous phase was extracted with ether and the organic phases were combined and washed sequentially twice with water and once with brine. Finally, the organic phase was concentrated to give a brown oil, which solidified to the target product 3-bromo-4-chloro-5-nitropyridine in a yield of 8.01 g (yield >100%) after standing.

References[1] Patent: WO2005/37198, 2005, A2. Location in patent: Page/Page column 26-27
[2] Tetrahedron Letters, 2012, vol. 53, # 4, p. 377 - 379
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2462 - 2471
[4] Justus Liebigs Annalen der Chemie, 1937, vol. 529, p. 291
Tag:3-BROMO-4-CHLORO-5-NITROPYRIDINE(31872-63-6) Related Product Information
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