- Pivaloylacetonitrile
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- $0.00 / 10KG
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2025-10-24
- CAS:59997-51-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20MT
- Pivaloylacetonitrile
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- $9.90 / 1KG
-
2025-10-21
- CAS:59997-51-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- Pivaloylacetonitrile
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- $0.00 / 25KG
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2025-08-08
- CAS:59997-51-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
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| | Pivaloylacetonitrile Basic information |
| Product Name: | Pivaloylacetonitrile | | Synonyms: | 4,4-Dimethyl-3-oxopentanenitrile
4,4-Dimethyl-3-oxovaleronitrile;Pivaloylacetonitrile, 97% 100GR;Pivaloylacetonitrile, 97% 25GR;Pivaloylacetonitrile, 97% 500GR;Pivaloylacetonitrile, 1-Cyano-3,3-dimethylbutan-2-one, 4,4-Dimethyl-3-oxovaleronitrile;Pyvaolylacetonitrile;Pivaloylacetonitrile ,98%;4,4-diMethyl-3-O E nitrile | | CAS: | 59997-51-2 | | MF: | C7H11NO | | MW: | 125.17 | | EINECS: | 262-017-1 | | Product Categories: | Agrochemicals;Aliphatics;ketone;BUILDING BLOCKS | | Mol File: | 59997-51-2.mol |  |
| | Pivaloylacetonitrile Chemical Properties |
| Melting point | 66-69 °C(lit.) | | Boiling point | 125-126 °C22 mm Hg(lit.) | | density | 1.0459 (rough estimate) | | refractive index | 1.4693 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 10.25±0.10(Predicted) | | form | Crystals or Crystalline Powder | | color | White to cream | | Water Solubility | Insoluble in water. | | BRN | 1746674 | | InChI | InChI=1S/C7H11NO/c1-7(2,3)6(9)4-5-8/h4H2,1-3H3 | | InChIKey | MXZMACXOMZKYHJ-UHFFFAOYSA-N | | SMILES | C(#N)CC(=O)C(C)(C)C | | CAS DataBase Reference | 59997-51-2(CAS DataBase Reference) | | NIST Chemistry Reference | 4,4-Dimethyl-3-oxopentanenitrile(59997-51-2) | | EPA Substance Registry System | Pentanenitrile, 4,4-dimethyl-3-oxo- (59997-51-2) |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 36/37/39-45 | | RIDADR | UN 3439 6.1/PG 3 | | WGK Germany | 3 | | RTECS | SA2991000 | | F | 8 | | TSCA | Yes | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29269090 |
| | Pivaloylacetonitrile Usage And Synthesis |
| Chemical Properties | white to cream crystals or crystalline powder | | Uses | Trimethylacetylacetonitrile is a useful intermediate. 4,4-Dimethyl-3-oxopentanenitrile has been used in the preparation of 4,4-dimethyl-3-oxo-2-benzylpentanenitrile, 4,4-dimethyl-3-oxo-2-(4-hydroxybenzyl)pentanenitrile, 4,4-dimethyl-3-oxo-2-(4-methoxybenzyl)pentanenitrile, 4,4-dimethyl-3-oxo-2-(4-fluorobenzyl)pentanenitrile, 4,4-dimethyl-3-oxo-2-(3,4-methylenedioxybenzyl)pentanenitrile, 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-phenylurea. | | Synthesis | 1. NaH (50% in paraffin oil, 1.2 eq., 4.6 g) was added to 1,4-dioxane (120 ml) and stirred for several minutes to disperse the mixture.
2. Acetonitrile (1.2 eq., 4.2 g) was slowly added dropwise to the above mixture over a period of 15 minutes and stirring was continued for 30 minutes after completion of the addition.
3. Methyl pivalate (1 eq., 10 g) was added slowly and dropwise to the reaction system over 15 minutes, after which the reaction mixture was heated to reflux for 3 hours.
4. After completion of the reaction, the reaction mixture was poured into ice water (200 g) and the pH was adjusted to 4.5 with acid.
5. The aqueous phase was extracted several times with dichloromethane (12 x 250 ml) and the organic phase was combined.
6. The combined organic phases were dried with anhydrous sodium sulfate, filtered and concentrated.
7. The concentrate was recrystallized with hexane (100 ml) to give the brown solid product 4,4-dimethyl-3-oxopentanenitrile (5 g, 51% yield). | | References | [1] Tetrahedron, 1993, vol. 49, # 23, p. 5091 - 5098
[2] Journal of the Chemical Society, Chemical Communications, 1992, # 1, p. 50 - 51
[3] Patent: WO2010/127855, 2010, A1. Location in patent: Page/Page column 95
[4] Patent: WO2010/127856, 2010, A1. Location in patent: Page/Page column 78
[5] Patent: US2012/46301, 2012, A1. Location in patent: Page/Page column 28; 29 |
| | Pivaloylacetonitrile Preparation Products And Raw materials |
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