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| | GRAYANOTOXIN III Basic information |
| Product Name: | GRAYANOTOXIN III | | Synonyms: | (14R)-Grayanotoxane-3β,5,6β,10,14,16-hexol;Grayanotoxin III Hemi(ethyl acetate);4,8-tetramethyl-,(2s,3as,4r,4ar,7r,8r,9as,11r,11ar,12r)-1;6,10,14,16-hexol,(3-beta,6-beta,14r)-grayanotoxane-5;andromedol;deacetylandromedotoxin;deacylasebotoxini;GRAYANOTOXIN 3.1/2 ETHYL ACETATE ADDUCT | | CAS: | 4678-45-9 | | MF: | C20H34O6 | | MW: | 370.48 | | EINECS: | | | Product Categories: | Monovalent Ion Channels;Other Sodium Channel Modulators;Sodium Channel Modulators | | Mol File: | 4678-45-9.mol |  |
| | GRAYANOTOXIN III Chemical Properties |
| Melting point | 218 °C (decomp) | | Boiling point | 552.6±50.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
Water: Slightly Soluble: 0.1-1 mg/ml | | pka | 13.79±0.70(Predicted) |
| Hazard Codes | T | | Risk Statements | 23/24/25-36/38 | | Safety Statements | 22-26-36/37/39-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | PB9190000 | | HazardClass | 6.1(a) | | PackingGroup | I | | Toxicity | LD50 i.p. in mice: 0.84 mg/kg (Hikino, 1976) |
| | GRAYANOTOXIN III Usage And Synthesis |
| Description | Grayanotoxin III (GTX-III) is a diterpene toxin that has been found in R. ponticum nectar, a component of mad honey.1 In vivo, GTX-III (0.1 and 0.25 mg/kg) induces salivation, emesis, and hind paw paralysis in mice.2 It is lethal to mice (LD50 = 0.84 mg/kg).WARNING This product is not for human or veterinary use. | | Hazard | A poison | | References | [1] ARZUM BAHAR KURTOGLU Gulsun A E Recep Yavuz. Characterisation and fate of grayanatoxins in mad honey produced from Rhododendron ponticum nectar[J]. Food Chemistry, 2014, 161: Pages 47-52. DOI: 10.1016/j.foodchem.2014.03.127
[2] T. OHGAKI . Preventive action of quisqualic acid against grayanotoxin-induced suppression of locomotor activity in mice[J]. Neuropharmacology, 1988, 27 10: Pages 1045-1053. DOI: 10.1016/0028-3908(88)90066-4 |
| | GRAYANOTOXIN III Preparation Products And Raw materials |
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