- H-L-Glu(OEt)-OEt·HCl
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- $0.00 / 1kg
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2026-01-06
- CAS:1118-89-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
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| | Diethyl L-glutamate hydrochloride Basic information |
| | Diethyl L-glutamate hydrochloride Chemical Properties |
| Melting point | 108-110 °C(lit.) | | refractive index | 22.5 ° (C=3.6, EtOH) | | storage temp. | Inert atmosphere,Room Temperature | | Water Solubility | Soluble in water | | form | powder to crystal | | color | White to Almost white | | Optical Rotation | [α]18/D +22°, c = 1 in H2O | | BRN | 3597595 | | InChI | InChI=1/C9H17NO4.ClH/c1-3-13-8(11)6-5-7(10)9(12)14-4-2;/h7H,3-6,10H2,1-2H3;1H/t7-;/s3 | | InChIKey | WSEQLMQNPBNMSL-WMASNCOMNA-N | | SMILES | C(CC(=O)OCC)[C@H](N)C(=O)OCC.Cl |&1:7,r| | | CAS DataBase Reference | 1118-89-4(CAS DataBase Reference) | | EPA Substance Registry System | L-Glutamic acid, diethyl ester, hydrochloride (1118-89-4) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | MA1252280 | | TSCA | TSCA listed | | HS Code | 29224210 | | Toxicity | mouse,LD50,intraperitoneal,> 2gm/kg (2000mg/kg),Pharmaceutical Chemistry Journal Vol. 25, Pg. 246, 1991. |
| | Diethyl L-glutamate hydrochloride Usage And Synthesis |
| Chemical Properties | White crystal | | Uses | L-Glutamic Acid Diethyl Ester Hydrochloride is a derivative of L-Glutamic Acid (G596960), a non-essential amino acid. | | Uses | L-Glutamic acid diethyl ester hydrochloride can be used in the synthesis of:
- Oligo(γ-ethyl L-glutamate) via oligomerization catalyzed by papain.
- L-glutamic acid based dendritic compounds.
- Poly(α-peptide) by polymerization and copolymerization in the presence of protease catalysts.
| | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | To a 500 mL four-necked round-bottomed flask equipped with a mechanical stirrer, a thermometer and a reflux condenser tube (connected to a 30% aqueous sodium hydroxide solution absorption system), 300 g of ethanol, 14.7 g (0.10 mol) of L-glutamic acid, and 25.0 g (0.08 mol) of triphosgene were added sequentially. The reaction mixture was heated to 70-75°C and maintained at this temperature with stirring for 5 hours. Upon completion of the reaction, the system was cooled to 20-25°C and the hydrogen chloride gas generated in the system was removed by nitrogen displacement, a process that lasted for 30 minutes. Subsequently, the excess triphosgene and ethanol were recovered by distillation. To the residue, 100 mL of methyl tert-butyl ether was added for pulping, and after filtration and drying, 23.5 g of the white solid product L-glutamic acid diethyl ester hydrochloride was obtained. The product was analyzed by liquid chromatography with 99.7% purity and 98.0% yield. | | References | [1] Synthetic Communications, 2010, vol. 40, # 8, p. 1161 - 1179
[2] Patent: CN107602436, 2018, A. Location in patent: Paragraph 0051; 0052
[3] Patent: CN108218739, 2018, A. Location in patent: Paragraph 0116; 0117
[4] Chemistry of Natural Compounds, 1994, vol. 30, # 2, p. 238 - 244
[5] Khimiya Prirodnykh Soedinenii, 1994, # 2, p. 261 - 268 |
| | Diethyl L-glutamate hydrochloride Preparation Products And Raw materials |
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