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| | 2-METHANESULFONYL-PYRIMIDINE Basic information | | Application |
| Product Name: | 2-METHANESULFONYL-PYRIMIDINE | | Synonyms: | Methyl pyrimidin-2-yl sulphone;2-METHANESULFONYL-PYRIMIDINE;2-(Methylsulfonyl)pyrimidine;2-METHANESULFONYL-PYRIMIDINE ISO 9001：2015 REACH;Pyrimidine, 2-(methylsulfonyl)- | | CAS: | 14161-09-2 | | MF: | C5H6N2O2S | | MW: | 158.18 | | EINECS: | | | Product Categories: | | | Mol File: | 14161-09-2.mol |  |
| | 2-METHANESULFONYL-PYRIMIDINE Chemical Properties |
| Boiling point | 335.6±25.0 °C(Predicted) | | density | 1.344±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | solid | | pka | -3.39±0.13(Predicted) | | color | Yellow |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2933599590 |
| | 2-METHANESULFONYL-PYRIMIDINE Usage And Synthesis |
| Application | 2-Methylsulfonylpyrimidine can be used as a pharmaceutical synthesis intermediate and an organic synthesis intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical synthesis processes. | | Synthesis | 2-Methylsulfonylpyrimidine was prepared as follows: a suspension of potassium carbonate (27.6 g, 0.2 mol) in a solution of 2-mercaptopyrimidine (0.1 mol) and methyl iodide (18.7 ml, 0.3 mol) in acetone (200 ml) was heated to reflux for a period of 3 hours. The reaction mixture was allowed to cool and then filtered followed by vacuum evaporation. Distillation of the mixture at a pressure of 0.01 mmHg gave 12.7 g of 2-methylthio-4,6-dimethylpyrimidine as a white solid. A portion of this solid (4.42 g, 28.7 mmol) was dissolved in dichloromethane (200 ml) and m-chloroperoxybenzoic acid (50%, 22.8 g, 66.0 mmol) was added in batches. The resulting mixture was stirred for 5 days and finally it was filtered and then evaporated under vacuum. Purification by rapid column chromatography on silica gel, using ether as eluent, gave 2-methylsulfonylpyrimidine as a white solid, m.pt., 81 C. |
| | 2-METHANESULFONYL-PYRIMIDINE Preparation Products And Raw materials |
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