FLUPHENAZINE DIMALEATE

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Company Name: Shaanxi Dideu Medichem Co. Ltd
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Products Intro: Product Name:FLUPHENAZINE DIMALEATE
CAS:3093-66-1
Purity:99% Package:1KG;1USD
Company Name: DAYANG CHEM (HANGZHOU) CO.,LTD
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Products Intro: Product Name:Fluphenazine dimaleate salt
CAS:3093-66-1
Purity:0.95&0.99 Package:0.1KG;1KG;1000KG Remarks:High quality
Company Name: Santa Cruz Biotechnology Inc  
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Products Intro: Product Name:Fluphenazine dimaleate salt
CAS:3093-66-1
Company Name: Shanghai Xiyuan Biotechnology Co., Ltd  
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Products Intro: Product Name:Fluphenazine Dimaleate, 98.0+ % (Titration)
CAS:3093-66-1
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FLUPHENAZINE DIMALEATE manufacturers

FLUPHENAZINE DIMALEATE Basic information
Product Name:FLUPHENAZINE DIMALEATE
Synonyms:FLUPHENAZINE DIMALEATE;Fluphenazine maleate;Fluphenazine Dimaleate, 98.0+ % (Titration)
CAS:3093-66-1
MF:C30H34F3N3O9S
MW:669.6658696
EINECS:
Product Categories:Enzyme Inhibitors;Enzyme Inhibitors by Type;Substrate Analogs
Mol File:3093-66-1.mol
FLUPHENAZINE DIMALEATE Structure
FLUPHENAZINE DIMALEATE Chemical Properties
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36
RIDADR 3249
WGK Germany 3
HazardClass 6.1(b)
PackingGroup III
MSDS Information
ProviderLanguage
SigmaAldrich English
FLUPHENAZINE DIMALEATE Usage And Synthesis
UsesFluphenazine dimaleate is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dimaleate blocks neuronal voltage-gated sodium channels. Fluphenazine dimaleate acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dimaleate can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dimaleate can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][6].
in vivo

Fluphenazine (1 mg/kg; IG, treated from day 6 to day 15 of gestation) causes malformations in pregnant mice[5].
Fluphenazine (0.125-1 mg/kg; IP, single dosage) antagonizes Methylphenidate-induced stereotyped gnawing; inhibits significantly climbing behaviour[6].

Animal Model:Mature female Swiss-Webster mice[5]
Dosage:1 mg/kg
Administration:IG, treated from day 6 to day 15 of gestation
Result:Significantly reduced fetal weight and length, increased the incidence of incomplete ossification of sternebrae and skull bones.
Animal Model:Mice (injected with 60 mg/kg Methylphenidate)[6]
Dosage:0.125, 0.25, 0.5, and 1 mg/kg
Administration:IP, single dosage
Result:Antagonized Methylphenidate-induced stereotyped gnawing; inhibited significantly climbing behaviour in mice at 0.0625-0.5 mg/kg, and at the dose of 1 mg/kg abolished this effect completely.
References[1] Zhou X, et al. The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels. Brain Res. 2006 Aug 23;1106(1):72-81. DOI:10.1016/j.brainres.2006.05.076
[2] Nazeam J, et al. Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and ProlixinRX (Fluphenazine) Provides Off-Label Drug Candidates. SLAS Discov. 2020 Dec;25(10):1123-1140. DOI:10.1177/2472555220950236
[3] Siragusa S, Bistas KG, Saadabadi A. Fluphenazine. 2022 May 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. PMID:29083807
[4] Davis JL, et al. Peripheral diabetic neuropathy treated with amitriptyline and fluphenazine. JAMA. 1977 Nov 21;238(21):2291-2. PMID:29083807
[5] Abdel-Hamid HA, et al. Teratogenic effect of diphenylhydantoin and/or fluphenazine in mice. J Appl Toxicol. 1996 May-Jun;16(3):221-5. DOI:10.1002/(SICI)1099-1263(199605)16:33.0.CO;2-Q
[6] Langwiński R, Niedzielski J. Narcotic analgesics and stereotyped behaviour in mice. Naunyn Schmiedebergs Arch Pharmacol. 1980 Jul;312(3):225-7. DOI:10.1007/BF00499150
FLUPHENAZINE DIMALEATE Preparation Products And Raw materials
Tag:FLUPHENAZINE DIMALEATE(3093-66-1) Related Product Information
Tris(2,4-pentanedionato)chroMiuM(III) Cupric acetylacetonate Benzyl isocyanide N-BUTYLISOCYANIDE Aluminum acetylacetonate PHENYLSELENOL DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Ferric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) SALCOMINE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) COBALT(II) ACETYLACETONATE Tosylmethyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE TERT-BUTYL ISOCYANIDE Ethyl isocyanoacetate FLUPHENAZINE

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