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| | 3-Chlorophenol Basic information |
| | 3-Chlorophenol Chemical Properties |
| Melting point | 31-34 °C (lit.) | | Boiling point | 214 °C (lit.) | | density | 1.218 g/mL at 25 °C (lit.) | | vapor pressure | 1 hPa (44 °C) | | refractive index | n20/D 1.563(lit.) | | Fp | >230 °F | | storage temp. | Store below +30°C. | | solubility | Soluble in ethanol and ether. | | pka | 8.85(at 25℃) | | form | Liquid After Melting | | color | Clear yellow to brownish | | Odor | distinct phenol-like odor | | PH | 3.5 (27.7g/l, H2O, 20℃) | | Water Solubility | 27.7 g/L (20 ºC) | | Merck | 14,2154 | | BRN | 1634401 | | Henry's Law Constant | 7.2×100 mol/(m3Pa) at 25℃, Chao et al. (2017) | | Stability: | Stable. Combustible. Incompatible with acid chlorides, oxidizing agents, acid anhydrides. Discolours in air. | | InChI | 1S/C6H5ClO/c7-5-2-1-3-6(8)4-5/h1-4,8H | | InChIKey | HORNXRXVQWOLPJ-UHFFFAOYSA-N | | SMILES | Oc1cccc(Cl)c1 | | CAS DataBase Reference | 108-43-0(CAS DataBase Reference) | | NIST Chemistry Reference | Phenol, 3-chloro-(108-43-0) | | EPA Substance Registry System | m-Chlorophenol (108-43-0) |
| Hazard Codes | Xn,N | | Risk Statements | 20/21/22-51/53 | | Safety Statements | 28-61-28A | | RIDADR | UN 2020 6.1/PG 3 | | WGK Germany | 2 | | RTECS | SK2450000 | | F | 9 | | Autoignition Temperature | >600 °C | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29081000 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Aquatic Chronic 2
Eye Dam. 1
Skin Irrit. 2 | | Hazardous Substances Data | 108-43-0(Hazardous Substances Data) | | Toxicity | LD50 orally in rats: 0.57 g/kg (Deichmann) |
| | 3-Chlorophenol Usage And Synthesis |
| Chemical Properties | White to light yellow crystal. | | Chemical Properties | All isomers have a characteristic odor. | | Uses | 3-Chlorophenol is a halophenol with antifungal activity. 3-Chlorophenol is commonly used as a building block in the preparation of variety of biologically active compounds. Studies suggest that 3-Chlo
rophenol can be used in the regeneration of vegetal activated carbons. | | Uses | 3-Chlorophenol is widely used in the pharmaceutical, dyes and organic synthesis industry. It is an important intermediate in the synthesis of chemicals. | | Uses | 3-Chlorophenol is generally used in building various polycyclic aromatic systems. It is also employed in palladium-catalyzed coupling reactions to synthesize aryl intermediates in synthetic organic chemistry. | | Definition | ChEBI: 3-chlorophenol is a monochlorophenol carrying the chloro substituent at position 3. | | General Description | White crystals with an odor of phenol. Sinks in and slowly dissolves in water. | | Air & Water Reactions | Discolors on exposure to air. Water soluble | | Reactivity Profile | 3-Chlorophenol is incompatible with acid chlorides, acid anhydrides and oxidizing agents . | | Hazard | Toxic by skin absorption, inhalation, or
ingestion. | | Fire Hazard | 3-Chlorophenol is probably combustible. | | Safety Profile | Poison by
intraperitoneal route. Moderately toxic by
ingestion and subcutaneous routes.
Questionable carcinogen with experimental
tumorigenic data by skin contact. Mutation
data reported. Flammable or combustible
liquid. When heated to decomposition it
emits toxic fumes of Cl-. See also
CHLOROPHENOLS. | | Potential Exposure | Monochlorophenols are used in the
manufacture of fungicides, slimicides, bactericides, pesticides, herbicides, disinfectants, wood and glue preservatives; in the production of phenolic resins; in the extraction
of certain minerals from coal; as a denaturant for ethanol;
as an antiseptic; as a disinfectant, and others. | | Shipping | UN 2020 (solid); UN2021 (liquid) Chlorophenols, solid and liquid, Hazard Class: 6.1; Labels:
6.1-Poisonous materials. | | Purification Methods | It could not be obtained solid by crystallisation from pet ether. It is best purified by distillation under reduced pressure. [Beilstein 6 IV 810.] | | Incompatibilities | May form explosive mixture with air.
Contact with oxidizing agents can cause fire and explosion
hazard. Heat produces hydrogen chloride and chlorine.
Corrosive to aluminum, copper and other chemically active
metals. | | Waste Disposal | Incinerate in admixture with
flammable solvent in furnace equipped with afterburner
and scrubber. |
| | 3-Chlorophenol Preparation Products And Raw materials |
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