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| | N-METHYL MESOPORPHYRIN IX Basic information |
| Product Name: | N-METHYL MESOPORPHYRIN IX | | Synonyms: | N-METHYL MESOPORPHYRIN IX;21H,23H-Porphine-2,18-dipropanoic acid, 8,13-diethyl-3,7,12,17,23-pentamethyl-;21H,23H-Porphine-2,18-dipropanoic acid, 8,13-diethyl-3,7,12,17,23-pentamethyl- (9ci);8,13-Diethyl-3,7,12,17,23-pentamethyl-21H,23H-porphine-2,18-dipropanoic acid;3,3'-(8,13-Diethyl-3,7,12,17,23-pentamethylporphyrin-2,18-diyl)dipropionic acid;3-[20-(2-carboxyethyl)-10,15-diethyl-5,9,14,19,22-pentamethyl-21,22,23,24-tetraazapentacyclo[16.2.1.13,?.1?,11.113,1?]tetracosa-1,3,5,7,9,11(23),12,14,16,18(21),19-undecaen-4-yl]propanoic acid | | CAS: | 142234-85-3 | | MF: | C35H40N4O4 | | MW: | 580.72 | | EINECS: | | | Product Categories: | Porphyrins | | Mol File: | Mol File |  |
| | N-METHYL MESOPORPHYRIN IX Chemical Properties |
| density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.17 mg/ml; DMSO: 15 mg/ml | | form | A crystalline solid | | color | Brown to black |
| | N-METHYL MESOPORPHYRIN IX Usage And Synthesis |
| Uses | N-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies[1]. | | References | [1] Meng Li, et al. N-Methyl Mesoporphyrin IX as an Effective Probe for Monitoring Alzheimer's Disease β-Amyloid Aggregation in Living Cells. ACS Chem Neurosci. 2017 Jun 21;8(6):1299-1304. DOI:10.1021/acschemneuro.6b00436 |
| | N-METHYL MESOPORPHYRIN IX Preparation Products And Raw materials |
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