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| | IFLAB-BB F2124-0088 Basic information |
| | IFLAB-BB F2124-0088 Chemical Properties |
| Boiling point | 340.8±42.0 °C(Predicted) | | density | 1.309±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 2.73±0.10(Predicted) |
| | IFLAB-BB F2124-0088 Usage And Synthesis |
| Synthesis | General procedure: A mixed solution of 5-amino-4,6-dichloropyrimidine (1.0 mmol), triethylamine (1.0 mmol), ethanol (4.3 mL) and n-propylamine (2.5 mmol) was placed in an autoclave reactor, heated to a specified temperature and kept for a period of time. After completion of the reaction, the volatile components were evaporated under reduced pressure and the crude product was purified according to a specific method to obtain the target compound 6-chloro-N4-propyl-4,5-pyrimidinediamine. | | References | [1] European Journal of Medicinal Chemistry, 2018, vol. 151, p. 199 - 213
[2] Journal of Medicinal Chemistry, 1997, vol. 40, # 20, p. 3207 - 3216
[3] Patent: WO2014/75393, 2014, A1. Location in patent: Page/Page column 175
[4] Organic Letters, 2017, vol. 19, # 23, p. 6360 - 6363 |
| | IFLAB-BB F2124-0088 Preparation Products And Raw materials |
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