- 2'-Fluoroacetanilide
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- $1.10 / 1g
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2022-07-30
- CAS:399-31-5
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- 2'-Fluoroacetanilide
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- $0.00 / 1KG
-
2022-01-15
- CAS:399-31-5
- Min. Order: 1KG
- Purity: 99.1%
- Supply Ability: 100 tons
- 2'-Fluoroacetanilide
-
- $1.00 / 1g
-
2020-01-15
- CAS:399-31-5
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 10000KGS
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| | 2'-Fluoroacetanilide Basic information |
| | 2'-Fluoroacetanilide Chemical Properties |
| Melting point | 77-79 °C(lit.) | | Boiling point | 140-142 °C14 mm Hg(lit.) | | density | 1.1655 (estimate) | | Fp | 140-142°C/14mm | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | pka | 14.04±0.70(Predicted) | | form | Fine Crystalline Powder | | color | White | | BRN | 2717443 | | CAS DataBase Reference | 399-31-5(CAS DataBase Reference) | | NIST Chemistry Reference | Acetamide, N-(2-fluorophenyl)-(399-31-5) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29242998 |
| | 2'-Fluoroacetanilide Usage And Synthesis |
| Chemical Properties | white fine crystalline powder | | Uses | 2''-Fluoroacetanilide | | Synthesis | Step 1: Synthesis of N-(2-fluorophenyl)acetamide
To a solution of 2-fluoroaniline (5.0 g, 45.05 mmol) in dichloromethane (DCM, 225 mL) was sequentially added acetic anhydride (4.09 mL, 45.05 mmol) and triethylamine (7.55 mL, 54.05 mmol). The reaction mixture was stirred at room temperature for 6 hours. After completion of the reaction, the mixture was concentrated, diluted with ethyl acetate and washed with 1N hydrochloric acid (2 x 50 mL). The organic phase was dried with anhydrous sodium sulfate (Na2SO4) and concentrated to give N-(2-fluorophenyl)acetamide (6.20 g, 90% yield) as a white solid.LCMS analysis showed the molecular ion peak of the target product to be 153.99 (M + H)+. | | References | [1] Journal of Medicinal Chemistry, 2003, vol. 46, # 11, p. 2187 - 2196
[2] Patent: US2008/139558, 2008, A1. Location in patent: Page/Page column 80
[3] Journal of the Chemical Society - Perkin Transactions 1, 1996, # 7, p. 669 - 673
[4] Patent: US2012/238543, 2012, A1. Location in patent: Page/Page column 13
[5] Patent: US2012/270854, 2012, A1. Location in patent: Page/Page column 20 |
| | 2'-Fluoroacetanilide Preparation Products And Raw materials |
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