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| | 3-FLUOROPHENETHYL ALCOHOL Basic information |
| Product Name: | 3-FLUOROPHENETHYL ALCOHOL | | Synonyms: | 2-(M-FLUOROPHENYL)ETHANOL;(3-FLUORO-PHENYL)-ACETALDEHYDE;2-(3-fluorophenyl)acetaldehyde;Benzeneacetaldehyde, 3-fluoro-;3-fluoroBenzeneacetaldehyde | | CAS: | 75321-89-0 | | MF: | C8H7FO | | MW: | 138.14 | | EINECS: | | | Product Categories: | | | Mol File: | 75321-89-0.mol |  |
| | 3-FLUOROPHENETHYL ALCOHOL Chemical Properties |
| Boiling point | 90 °C3 mm Hg(lit.) | | density | 1.125 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.509(lit.) | | Fp | 225 °F | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | form | solid |
| | 3-FLUOROPHENETHYL ALCOHOL Usage And Synthesis |
| Synthesis | 2-(3-Fluorophenyl)acetaldehyde was synthesized by oxidation reaction using 3-fluorophenethyl alcohol as starting material. The steps were as follows: 1. 3-Fluorophenyl ethanol was reacted with an oxidizing agent (e.g., PCC or Swern oxidizing reagent) in a suitable solvent at 0 °C to room temperature. 2. After completion of the reaction, the target product, 2-(3-fluorophenyl)acetaldehyde, was obtained by extraction and purification by column chromatography. This synthetic route is efficient and selective and is suitable for laboratory scale preparation. | | References | [1] Patent: WO2008/36294, 2008, A2. Location in patent: Page/Page column 4; 6/8
[2] Patent: WO2008/42353, 2008, A1. Location in patent: Page/Page column 35; 41-42
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 3, p. 779 - 797
[4] Patent: WO2012/97121, 2012, A2. Location in patent: Page/Page column 14
[5] Patent: WO2008/42353, 2008, A1. Location in patent: Page/Page column 35; 41-42 |
| | 3-FLUOROPHENETHYL ALCOHOL Preparation Products And Raw materials |
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