| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
BRD5648 manufacturers
- BRD5648
-
- $38.00
-
2026-07-27
- CAS:2056261-42-6
- Purity: 99.89%
- Supply Ability: 10g
- BRD5648
-
- $38.00
-
2026-07-27
- CAS:2056261-42-6
- Purity: 99.89%
- Supply Ability: 10g
|
| | BRD5648 Basic information |
| Product Name: | BRD5648 | | Synonyms: | BRD5648;(R)-BRD0705;compound,Glycogen synthase kinase 3,negative,Glycogen synthase kinase-3,BRD-5648,GSK-3,BRD5648,inhibit,BRD 5648,Inhibitor,(R)-enantiomer,control;5H-Pyrazolo[3,4-b]quinolin-5-one, 4-ethyl-1,2,4,6,7,8-hexahydro-7,7-dimethyl-4-phenyl-, (4R)-;BRD5648, 10 mM in DMSO;(4R)-4-Ethyl-7,7-dimethyl-4-phenyl-1,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one | | CAS: | 2056261-42-6 | | MF: | C20H23N3O | | MW: | 321.42 | | EINECS: | | | Product Categories: | | | Mol File: | 2056261-42-6.mol |  |
| | BRD5648 Chemical Properties |
| Boiling point | 512.0±50.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | pka | 14.82±0.60(Predicted) | | form | Solid | | color | Light yellow to khaki |
| | BRD5648 Usage And Synthesis |
| Description | BRD5648 is an inactive (R)-enantiomer of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor. It can be used for acute myeloid leukemia (AML). | | Uses | BRD5648 ((R)-BRD0705) is a negative control of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2]. | | References | [1] Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. DOI:10.1126/scitranslmed.aam8460 |
| | BRD5648 Preparation Products And Raw materials |
|