ADRA1D receptor agonist 1
| 中文名称 | ADRA1D receptor agonist 1 |
|---|---|
| 中文同义词 | 化合物 T10250;ADRA1D RECEPTOR ANTAGONIST 1 盐酸盐 |
| 英文名称 | ADRA1D receptor agonist 1 |
| 英文同义词 | ADRA1D receptor agonist 1;ADRA1D receptor antagonist 1;ADRA-1D receptor antagonist 1,ADRA1D receptor antagonist 1;ADRA1D receptor antagonist 1 HCl |
| CAS号 | 1191908-14-1 |
| 分子式 | C15H14Cl2N4O |
| 分子量 | 337.2 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1191908-14-1.mol |
| 结构式 |  |
ADRA1D receptor agonist 1 性质
| 形态 | 固体 |
|---|---|
| 颜色 | 黄至棕色 |
ADRA1D receptor agonist 1 (compound (R)-9S) 是一个高效、选择性的，有口服活性的 α1D 肾上腺素受拮抗剂，Ki 值为 1.6 nM。
Ki: 1.6 nM (α 1D adrenoceptor)
ADRA1D receptor agonist 1 shows low hERG inhibition.
ADRA1D receptor agonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs .
ADRA1D receptor agonist 1 (4.4 µg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO.
| Animal Model: | Rat with bladder outlet obstruction (BOO) |
| Dosage: | 4.4 µg/kg |
| Administration: | Intravenous injection |
| Result: | Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-135270 | ADRA1D receptor antagonist 1 | 1191908-14-1 | 1 mg | 2181元 |
| 2026/06/05 | HY-135270 | ADRA1D receptor antagonist 1 | 1191908-14-1 | 5 mg | 4800元 |