| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:PF-06726304 acetate
CAS:2080306-28-9
Package:10mg/RMB 3780
|
| Company Name: |
R&D Systems, Inc
|
| Tel: |
18003437475 |
| Email: |
rdname@qq.com |
| Products Intro: |
Product Name:PF 06726304 acetate
CAS:2080306-28-9
|
PF-06726304 acetate manufacturers
- PF-06726304 acetate
-
- $783.00 / 10mg
-
2026-01-04
- CAS:2080306-28-9
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | PF-06726304 acetate Basic information | | Uses |
| | PF-06726304 acetate Chemical Properties |
| solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| | PF-06726304 acetate Usage And Synthesis |
| Uses | PF 06726304 Acetate is a useful research chemical. | | Uses | PF-06726304 acetate is a potent and selective EZH2 inhibitor. PF-06726304 acetate inhibits wild-type and Y641N mutant EZH2 with Kis of 0.7 and 3.0 nM, respectively. PF-06726304 acetate displays robust antitumor growth activity[1]. | | in vivo | PF-06726304 (200 and 300 mg/kg; BID for 20 days) inhibits tumor growth and induces robust modulation of downstream biomarkers in a subcutaneous Karpas-422 xenograft model[1]. | Animal Model: | Female Scid beige mice (6-8 weeks old) with Karpas-422 xenograft model[1] | | Dosage: | 200 and 300 mg/kg | | Administration: | Given BID for 20 days | | Result: | Inhibited tumor growth and induced robust modulation of downstream biomarkers in a subcutaneous Karpas-422 xenograft model. |
| | IC 50 | EZH2 WT: 0.7 nM (Ki); EZH2 Y641N: 3.0 nM (Ki) | | storage | Store at RT | | References | [1] Kung PP, et al. Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors. J Med Chem. 2016 Sep 22;59(18):8306-25. DOI:10.1021/acs.jmedchem.6b00515 |
| | PF-06726304 acetate Preparation Products And Raw materials |
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