Sparfosic acid trisodium
| 中文名称 | Sparfosic acid trisodium |
|---|---|
| 中文同义词 | N-(膦酰基乙酰基)-L-天门冬氨酸三钠盐;化合物 T12983;化合物 SPARFOSIC ACID TRISODIUM |
| 英文名称 | Sparfosic acid trisodium |
| 英文同义词 | Sparfosic acid trisodium;N-phosphonacetyl-L-aspartate trisodium |
| CAS号 | 70962-66-2 |
| 分子式 | C6H11NNaO8P |
| 分子量 | 279.12 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 70962-66-2.mol |
| 结构式 |  |
Sparfosic acid trisodium 性质
| 储存条件 | Store at -20°C |
|---|---|
| 形态 | 固液混合物 |
| 颜色 | 无色至类白色 |
| 水溶解性 | Water: 250 mg/mL (778.67 mM) |
Sparfosic acid trisodium 是天门冬氨酸氨甲酰转移酶 (aspartate transcarbamoyl transferase) 的有效抑制剂，具有抗肿瘤和抗代谢物活性。天冬氨酸氨甲酰转移酶催化第二步 de novo 嘧啶生物合成。
Sparfosic acid (PALA) treatment causes apoptosis in the resistant Br1 cells.
Sparfosic acid (PALA, 300 µM) shows progressive accumulation of cells in S phase and activation of an apoptotic pathway leading to cell death.
Cell Cycle Analysis
| Cell Line: | Br-l and L-2 cell lines established from metastasis in nude mouse injected with the human tumor cell line MDA-MB-435. |
| Concentration: | 300 µM. |
| Incubation Time: | 12, 24 and 48 h. |
| Result: | Cells were predominantly in S phase in both the cell lines, although slightly higher proportion of cells in S phase were noted in L-2 than Brl-3prl cells. |
Western Blot Analysis
| Cell Line: | Br-l and L-2 cell lines. |
| Concentration: | 300 µM. |
| Incubation Time: | 4, 10 and 24 h. |
| Result: |
There was moderate difference in the level of phosphorylated Rb proteins seen in the two cell types.
Marked increase in the amount of cyclin A protein was detected in the L-2 cells undergoing apoptosis with the highest level detected at 10 h post-drug treatment. In contrast, there was no increase in the level of cyclin A seen in the Brl-3prl cells. Cyclin E protein was found elevated in the L-2 cells and Brl-3prl cells compared to their respective controls. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-112732B | Sparfosic acid trisodium | 70962-66-2 | 1 mg | 1280元 |
| 2025/12/22 | HY-112732B | Sparfosic acid trisodium Sparfosic acid trisodium | 70962-66-2 | 5mg | 3200元 |