| Company Name: |
Energy Chemical |
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Company Name: |
cjbscvictory |
| Tel: |
13348960310 13348960310 |
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UCSF924 manufacturers
- UCSF924
-
- $80.00
-
2026-07-21
- CAS:1434515-70-4
- Purity:
- Supply Ability: 10g
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| | UCSF924 Basic information |
| Product Name: | UCSF924 | | Synonyms: | UCSF924;UCSF924 >=98% (HPLC);UCSF924,UCSF-924;4-Quinolinol, 6-methyl-2-[[(3-phenoxypropyl)amino]methyl]-;6-Methyl-2-{[(3-phenoxypropyl)amino]methyl}quinolin-4-ol | | CAS: | 1434515-70-4 | | MF: | C20H22N2O2 | | MW: | 322.4 | | EINECS: | | | Product Categories: | | | Mol File: | 1434515-70-4.mol |  |
| | UCSF924 Chemical Properties |
| Boiling point | 522.5±50.0 °C(Predicted) | | density | 1.174±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO:40.0(Max Conc. mg/mL);124.0(Max Conc. mM) | | pka | 4.08±0.40(Predicted) | | form | Solid | | color | White to off-white | | SMILES | CC1=CC=C(NC(CNCCCOC2=CC=CC=C2)=CC3=O)C3=C1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | UCSF924 Usage And Synthesis |
| Description | UCSF924 is a selective, high-affinity dopamine D4 receptor (DRD4) partial agonist (Ki = 3 nM for human D4) with a 7.4-fold bias toward arrestin recruitment over Gαi (Gαi/0; Gi/G0) signaling activation with respect to quinpirole. UCSF924 exhibits no detectable affinity for D2, D3 or the F261V/L328F D4 mutant and no agonist activity toward a panel of 320 nonolfactory GPCRs even at a high concentration of 1 μM. The UCSF924 structure analog UCSF924NC is the recommended negative control compound with a 1/2500-fold reduced D4 affinity. | | Uses | UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has no off-target effects on more than 320 non-olfactory GPCRs. UCSF924 can be used for research in the field of neuropsychiatric diseases[1][2]. | | IC 50 | D4 Receptor | | References | [1] Wang S, et al. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science. 2017 Oct 20;358(6361):381-386. DOI:10.1126/science.aan5468
[2] Thomas G E. Characterizing antipsychotic behavioral and corticostriatal neurophysiological effects to psychotomimetic challenge. Duke University, 2022. |
| | UCSF924 Preparation Products And Raw materials |
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