Methyltetrazine-amido-PEG5-alkyne manufacturers
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| | Methyltetrazine-amido-PEG5-alkyne Basic information |
| Product Name: | Methyltetrazine-amido-PEG5-alkyne | | Synonyms: | Methyltetrazine-amido-PEG5-alkyne;N-(4-(6-Methyl-1,2,4,5-tetrazin-3-yl)benzyl)-4,7,10,13,16-pentaoxanonadec-18-ynamide;N-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl]-3-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]propanamide;4,7,10,13,16-Pentaoxanonadec-18-ynamide, N-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl]- | | CAS: | 2322322-23-4 | | MF: | C24H33N5O6 | | MW: | 487.55 | | EINECS: | | | Product Categories: | | | Mol File: | 2322322-23-4.mol |  |
| | Methyltetrazine-amido-PEG5-alkyne Chemical Properties |
| density | 1.181±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, stored under nitrogen | | solubility | Soluble in DMSO, DCM, DMF | | pka | 14.29±0.46(Predicted) | | form | Solid | | color | Purple to purplish red |
| | Methyltetrazine-amido-PEG5-alkyne Usage And Synthesis |
| Description | Methyltetrazine-amido-PEG5-alkyne is a heterobifunctional crosslinker. This reagent enables simple and efficient incorporation of a tetrazine moiety onto TCO-attached antibodies, peptide or other biomolecule under mild condition. The alkynes is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry. PEG5 space increase the compound's aqueous solubility. | | Uses | Methyltetrazine-amido-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Methyltetrazine-amido-PEG5-alkyne Preparation Products And Raw materials |
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