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| | Furin Inhibitor II TFA Basic information |
| Product Name: | Furin Inhibitor II TFA | | Synonyms: | Furin Inhibitor II TFA;Hexa-D-arginine TFA;H-Arg6-NH2;(R)-2-amino-5-((diaminomethylene)amino)-N-((6R,9R,12R,15R,18R)-1,1,23,23-tetraamino-6-carbamoyl-9,12,15-tris(3-((diaminomethylene)amino)propyl)-8,11,14,17-tetraoxo-2,7,10,13,16,22-hexaazatricosa-1,22-dien-18-yl)pentanamide 2,2,2-trifluoroacetate;(S)-2-Amino-N-((6S,9S,12S,15S,18S)-1,23-diamino-6-carbamoyl-9,12,15-tris(3-guanidinopropyl)-1,23-diimino-8,11,14,17-tetraoxo-2,7,10,13,16,22-hexaazatricosan-18-yl)-5-guanidinopentanamide 2,2,2-trifluoroacetate | | CAS: | 958204-56-3 | | MF: | C36H75N25O6.C2HF3O2 | | MW: | 1068.17 | | EINECS: | | | Product Categories: | | | Mol File: | 958204-56-3.mol |  |
| | Furin Inhibitor II TFA Chemical Properties |
| form | Solid | | color | White to off-white | | Sequence | d(Arg-Arg-Arg-Arg-Arg-Arg)-NH2 |
| | Furin Inhibitor II TFA Usage And Synthesis |
| Uses | Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3]. | | in vivo | Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1]. | | References | [1] Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9. DOI:10.1128/IAI.70.12.7136-7139.2002
[2] Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5. DOI:10.1128/IAI.72.1.602-605.2004
[3] Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9. DOI:10.1074/jbc.M003848200 |
| | Furin Inhibitor II TFA Preparation Products And Raw materials |
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