AMY-101 TFA
| 中文名称 | AMY-101 TFA |
|---|---|
| 中文同义词 | 2-((4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-10-((1H-咪唑-5-基)甲基)-19-((1H-吲哚-3-Y基)甲基)-34-((2S,3S)-2-((R)-2-氨基-3-(4-羟基苯基)丙酰胺基)-3-甲基戊酰胺基)-4-(((2S,3S)-1-氨基-3-甲基-1-氧代戊-2-基)(甲基)氨基甲酰基)-25-(3-氨基-3-氧代丙基)-7-(3-胍基丙基)-31-异丙基-13,17-二甲基-28-((1-甲基-1H-吲哚-3-基)甲基)-6,9,12;化合物 AMY-101 TFA;2-((4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-10-((1H-咪唑-5-基)甲基)-19-((1H-吲哚-3-y基)甲基)-34-((2S,3S)-2-((R)-2-氨基-3-(4-羟基苯基)丙酰胺基)-3-甲基戊酰胺基)-4-(((2S,3S)-1-氨基-3-甲基-1-氧代戊-2-基)(甲基)氨基甲酰基)-25-(3-氨基-3-氧代丙基)-7-(3-胍基丙基)-31-异丙基-13,17-二甲基-28-((1-甲基-1H-吲哚-3-基)甲基)-6,9,12,15,18,21,24,27,30,33-十氧代-1,2-二硫杂-5,8,11,14,17,20,23,26,29,32-十氮杂环三十五烷-22-基)乙酸x三氟乙酸盐( |
| 英文名称 | Cp40 TFA |
| 英文同义词 | AMY-101 TFA;Cp40 TFA;2-((4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-10-((1H-imidazol-5-yl)methyl)-19-((1H-indol-3-yl)methyl)-34-((2S,3S)-2-((R)-2-amino-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-(((2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl)(methyl)carbamoyl)-25-(3-amino-3-oxopropyl)-7-(3-guanidinopropyl)-31-isopropyl-13,17-dimethyl-28-((1-methyl-1H-indol-3-yl)methyl)-6,9,12,15,18,21,24,27,30,33-decaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decaazacyclopentatriacontan-22-yl)acetic acid x2,2,2-Trifluoroacetic;2-((4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-10-((1H-imidazol-5-yl)methyl)-19-((1H-indol-3-yl)methyl)-34-((2S,3S)-2-((R)-2-amino-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-(((2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl)(methyl)carbamoyl)-25-(3-amino-3-oxopropyl)-7-(3-guanidinopropyl)-31-isopropyl-13,17-dimethyl-28-((1-methyl-1H-indol-3-yl)methyl)-6,9,12,15,18,21,24,27,30,33-decaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decaazacyclopentatriacontan-22-yl)acetic acid x2,2,2-Trifluoroacetic acid salt |
| CAS号 | 1789738-04-0 |
| 分子式 | C85H118F3N23O20S2 |
| 分子量 | 1903.14 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1789738-04-0.mol |
| 结构式 |  |
AMY-101 TFA 性质
| 形态 | 固体 |
|---|---|
| 颜色 | 白色至米白色 |
| 序列 | {D-Tyr}-Ile-Cys-Val-{Trp(Me)}-Gln-Asp-Trp-{Sar}-Ala-His-Arg-Cys-{N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13) |
AMY-101 TFA (Cp40 TFA) 是补体 C3 的肽类抑制剂 (KD = 0.5 nM)，可抑制非人类灵长类动物自然发生的牙周炎。AMY-101 TFA (Cp40 TFA) 在 COVID-19 重症肺炎合并全身超炎症模型中具有良好的抗炎活性。
KD: 0.5 nM (C3).
AMY-101 can improve the periodontal condition of NHPs with natural chronic periodontitis.
AMY-101 can induce a long-lasting anti-inflammatory effect.
AMY-101 (4 mg/kg bodyweight, subcutaneous injection. once per 24 hr for a total of 28 days) causes a significant and long-lasting reduction in PPD, an index that measures tissue destruction.
| Animal Model: | Fifteen adult male cynomolgus monkeys (Macaca fascicularis) (7-15 years old; 5.0-7.6 kg body weight). |
| Dosage: | 0.1 mg/site; 50 μL of 2 mg/mL solution. |
| Administration: | Injected locally. (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment.) |
| Result: | Does not cause irritation in healthy gingiva. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-P1717A | AMY-101 TFA | 1789738-04-0 | 1mg | 1200元 |
| 2026/09/15 | HY-P1717A | AMY-101 TFA | 1789738-04-0 | 5mg | 3200元 |