| Company Name: |
Shanghai Balmxy Pharmaceutical Co., Ltd
|
| Tel: |
021-24206007 13764915196 |
| Email: |
sales@balmxy.com |
| Products Intro: |
Product Name:2-Bromo-4-(pyrrolidin-1-yl)pyridine
CAS:230618-42-5
Purity:98%+ Package:5g;25g;100g;500g;1kg;5kg;25kg;100kg Remarks:BX30558
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| Company Name: |
Zhengzhou Alfachem Co., Ltd.
|
| Tel: |
0371-53765687 18937137882 |
| Email: |
3969243885@qq.com |
| Products Intro: |
Product Name:2-Bromo-4-(pyrrolidin-1-yl)pyridine
CAS:230618-42-5
Purity:98% Package:1g
|
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| | 2-BROMO-4-PYRROLIDIN-1-YL-PYRIDINE Basic information |
| | 2-BROMO-4-PYRROLIDIN-1-YL-PYRIDINE Chemical Properties |
| Melting point | 124 °C | | Boiling point | 335.5±27.0 °C(Predicted) | | density | 1.480±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 5.18±0.10(Predicted) |
| Hazard Codes | Xn | | Risk Statements | 22 |
| | 2-BROMO-4-PYRROLIDIN-1-YL-PYRIDINE Usage And Synthesis |
| Synthesis | 2,4-dibromopyridine (300 mg, 0.94 mmol) and pyrrolidine (335 mg, 4.7 mmol) were mixed in ethanol and reacted at 70 °C overnight. After completion of the reaction, the reaction mixture was concentrated under vacuum and the resulting residue was purified by ISCO column chromatography using a silica column with 0-70% ethyl acetate/pentane as eluent. The target product 2-bromo-4-(pyrrolidin-1-yl)pyridine (208 mg, 0.91 mmol, 97% yield) was finally obtained. The structure of the product was confirmed by 1H-NMR (CDCl3, 400 MHz): δ 2.0 (m, 4H), 3.3 (m, 4H), 6.3 (m, 1H), 6.6 (s, 1H), 7.9 (d, 1H).LRMS m/z (APCI) 227 [MH]+. | | References | [1] Patent: WO2007/57775, 2007, A1. Location in patent: Page/Page column 160 |
| | 2-BROMO-4-PYRROLIDIN-1-YL-PYRIDINE Preparation Products And Raw materials |
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