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Pyrano[3,4-d][1,3]thiazin-2-amine, 8a-(2,4-difluorophenyl)-4-(fluoromethyl)-4,4a,5,6,8,8a-hexahydro-6-(3-methyl-5-isoxazolyl)-, (4S,4aR,6R,8aS)- Suppliers list
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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marketing1@energy-chemical.com |
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Product Name:PF-06663195 >=98% (HPLC)
CAS:1621585-22-5
Purity:NULL Package:25mg;5mg Remarks:NULL
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| Company Name: |
TargetMol Chemicals Inc.
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15002134094 |
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marketing@targetmol.cn |
| Products Intro: |
Product Name:PF-06663195
CAS:1621585-22-5
Package:1removed
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
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ordercn@merckgroup.com |
| Products Intro: |
Product Name:PF-06663195
CAS:1621585-22-5
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Pyrano[3,4-d][1,3]thiazin-2-amine, 8a-(2,4-difluorophenyl)-4-(fluoromethyl)-4,4a,5,6,8,8a-hexahydro-6-(3-methyl-5-isoxazolyl)-, (4S,4aR,6R,8aS)- manufacturers
- PF-06663195
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- $1520.00
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2026-04-20
- CAS:1621585-22-5
- Purity:
- Supply Ability: 10g
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| | Pyrano[3,4-d][1,3]thiazin-2-amine, 8a-(2,4-difluorophenyl)-4-(fluoromethyl)-4,4a,5,6,8,8a-hexahydro-6-(3-methyl-5-isoxazolyl)-, (4S,4aR,6R,8aS)- Basic information |
| Product Name: | Pyrano[3,4-d][1,3]thiazin-2-amine, 8a-(2,4-difluorophenyl)-4-(fluoromethyl)-4,4a,5,6,8,8a-hexahydro-6-(3-methyl-5-isoxazolyl)-, (4S,4aR,6R,8aS)- | | Synonyms: | Pyrano[3,4-d][1,3]thiazin-2-amine, 8a-(2,4-difluorophenyl)-4-(fluoromethyl)-4,4a,5,6,8,8a-hexahydro-6-(3-methyl-5-isoxazolyl)-, (4S,4aR,6R,8aS)-;PF-06663195 >=98% (HPLC);PF-06663195 | | CAS: | 1621585-22-5 | | MF: | C18H18F3N3O2S | | MW: | 397.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1621585-22-5.mol | ![Pyrano[3,4-d][1,3]thiazin-2-amine, 8a-(2,4-difluorophenyl)-4-(fluoromethyl)-4,4a,5,6,8,8a-hexahydro-6-(3-methyl-5-isoxazolyl)-, (4S,4aR,6R,8aS)- Structure](CAS/20200611/GIF/1621585-22-5.gif) |
| | Pyrano[3,4-d][1,3]thiazin-2-amine, 8a-(2,4-difluorophenyl)-4-(fluoromethyl)-4,4a,5,6,8,8a-hexahydro-6-(3-methyl-5-isoxazolyl)-, (4S,4aR,6R,8aS)- Chemical Properties |
| Boiling point | 554.1±60.0 °C(Predicted) | | density | 1.55±0.1 g/cm3(Predicted) | | storage temp. | room temp | | solubility | DMSO: 20mg/mL, clear | | pka | 3.59±0.70(Predicted) | | form | powder | | color | white to beige | | InChI | 1S/C18H18F3N3O2S/c1-9-4-15(26-24-9)14-6-12-16(7-19)27-17(22)23-18(12,8-25-14)11-3-2-10(20)5-13(11)21/h2-5,12,14,16H,6-8H2,1H3,(H2,22,23)/t12-,14+,16+,18+/m0/s1 | | InChIKey | JIAYOIBUKDISBO-IYPIGGPWSA-N | | SMILES | [H][C@@]12[C@@](CO[C@@H](C3=CC(C)=NO3)C2)(C4=CC=C(F)C=C4F)N=C(N)S[C@@H]1CF |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Pyrano[3,4-d][1,3]thiazin-2-amine, 8a-(2,4-difluorophenyl)-4-(fluoromethyl)-4,4a,5,6,8,8a-hexahydro-6-(3-methyl-5-isoxazolyl)-, (4S,4aR,6R,8aS)- Usage And Synthesis |
| Description | PF-06663195 is a potent inhibitor of β-site amyloid precursor protein (APP) Cleaving Enzyme 1 (BACE1, β-Secretase 1). | | Uses | PF-06663195 is a β-secretase (BACE1) inhibitor, with BACE1 CFA and BACE1 WCA IC50 values of 53 and 15 nM, respectively. PF-06663195 can be used for Alzheimer's disease research[1]. | | References | [1] Michael A Brodney, et al. Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors. J Med Chem. 2015 Apr 9;58(7):3223-52. DOI:10.1021/acs.jmedchem.5b00191 |
| | Pyrano[3,4-d][1,3]thiazin-2-amine, 8a-(2,4-difluorophenyl)-4-(fluoromethyl)-4,4a,5,6,8,8a-hexahydro-6-(3-methyl-5-isoxazolyl)-, (4S,4aR,6R,8aS)- Preparation Products And Raw materials |
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