3-Pyridinecarboxamide, 2-amino-5-[3-(1-piperazinyl)phenyl]-N-4-pyridinyl-

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3-Pyridinecarboxamide, 2-amino-5-[3-(1-piperazinyl)phenyl]-N-4-pyridinyl- Basic information
Product Name:3-Pyridinecarboxamide, 2-amino-5-[3-(1-piperazinyl)phenyl]-N-4-pyridinyl-
Synonyms:3-Pyridinecarboxamide, 2-amino-5-[3-(1-piperazinyl)phenyl]-N-4-pyridinyl-;PKC-iota inhibitor 1;2-Amino-5-(3-(piperazin-1-yl)phenyl)-N-(pyridin-4-yl)nicotinamide;Protein kinase C,PKC iota inhibitor 1,Inhibitor,inhibit,PKC-iota inhibitor 1,PKC,PKCiota inhibitor 1;PKC-iota inhibitor 1, 10 mM in DMSO;2-Amino-5-[3-(1-piperazinyl)phenyl]-N-4-pyridinyl-3-pyridinecarboxamide
CAS:2328094-11-5
MF:C21H22N6O
MW:374.44
EINECS:
Product Categories:
Mol File:2328094-11-5.mol
3-Pyridinecarboxamide, 2-amino-5-[3-(1-piperazinyl)phenyl]-N-4-pyridinyl- Structure
3-Pyridinecarboxamide, 2-amino-5-[3-(1-piperazinyl)phenyl]-N-4-pyridinyl- Chemical Properties
Boiling point 590.5±50.0 °C(Predicted)
density 1.288±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 125 mg/mL (333.83 mM; Need ultrasonic)
pka10.49±0.70(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
3-Pyridinecarboxamide, 2-amino-5-[3-(1-piperazinyl)phenyl]-N-4-pyridinyl- Usage And Synthesis
UsesPKC-iota inhibitor 1 (compound 19) is a protein kinase C-iota (PKC-ι ) inhibitor with an IC50 value of 0.34 μM[1].
References[1] Kwiatkowski J, et al. Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues. ACS Med Chem Lett. 2019 Feb 15;10(3):318-323. DOI:10.1021/acsmedchemlett.8b00546
3-Pyridinecarboxamide, 2-amino-5-[3-(1-piperazinyl)phenyl]-N-4-pyridinyl- Preparation Products And Raw materials
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