| Company Name: |
Changzhou Chenhong Biotechnology Co., Ltd.
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| Tel: |
+86-0519-85788828 +86-13775037613 |
| Email: |
sales@chemrenpharm.com |
| Products Intro: |
Product Name:NS8593
CAS:875755-39-8
Purity:99% Package:50mg;100mg;250mg;500mg;1g;5g
|
| Company Name: |
Huai Hua Binfengchem Co., Ltd
|
| Tel: |
0745-2866851 17711757908 |
| Email: |
3907837691@qq.com |
| Products Intro: |
Product Name:NS8593
CAS:875755-39-8
Purity:98% Package:10mg，100mg，500mg，1g，10g
|
| Company Name: |
Shanghai Shengkun Biomedical Co., Ltd.
|
| Tel: |
15065661979 15065661979 |
| Email: |
stonebiopharm@163.com |
| Products Intro: |
Product Name:NS8593
CAS:875755-39-8
Purity:98% HPLC Package:5g，10g，25g，100g，500g，1kg，5kg
|
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| | 1H-Benzimidazol-2-amine, N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]- Basic information |
| | 1H-Benzimidazol-2-amine, N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]- Chemical Properties |
| Boiling point | 482.9±48.0 °C(Predicted) | | density | 1.273±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 100mg/mL | | pka | 11.37±0.10(Predicted) | | form | powder | | color | white | | InChIKey | XZIZUQSOFMLIIR-CQSZACIVSA-N | | SMILES | C1(NC(N[C@@H]2CCCC3=C2C=CC=C3)=N4)=C4C=CC=C1 |
| WGK Germany | WGK 2 | | Storage Class | 11 - Combustible Solids |
| | 1H-Benzimidazol-2-amine, N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]- Usage And Synthesis |
| Uses | An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels (SK1-3; Kd = 420 nM, 600 nM, and 730 nM for SK1, SK2, SK3, respectively) in a Ca2+-dependent manner. It mediates channel gating by interacting with gating structures deep within the inner pore vestibule where Ser507 and Ala532 are deemed to be important for inhibition. Interacts at a site that is distinct from the apamin binding site in SK channels. Can access high-affinity binding sites from both the inside and outside of the cell membrane. Does not affect QT intervals, but prolongs the atrial effective refractive period and prevents acetylcholine-induced atrial fibrillations in ex vivo and in vivo models. Also shown to reversibly block TRPM7 channel (IC50 = 1.6 mM) in smooth muscle cells, primary podocytes, HEK293 cells expressing TRPM7, and ventricular myocytes in a Mg2+-dependent manner and blocks the motility of cells in culture. |
| | 1H-Benzimidazol-2-amine, N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]- Preparation Products And Raw materials |
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