5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-

Request For Quotation
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro- Suppliers list
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 15026964105
Email: 2881489226@qq.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ：65489617 13301690235
Email: Sales@ATKchemical.com
Company Name: Shanghai SuperLan Chemcial Technique Centre  
Tel: 0-2022843681 15618226720
Email: chaolaichem@foxmail.com

5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro- manufacturers

  • JHU37152
  • JHU37152 pictures
  • $30.00
  • 2026-05-11
  • CAS:2369979-67-7
  • Purity: 99.72%
  • Supply Ability: 10g
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro- Basic information
Product Name:5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-
Synonyms:5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-;8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-5H-Dibenzo[b,e][1,4]diazepine;JHU37152,inhibit,hM3Dq,Clozapine,Inhibitor,DREADD,Muscarinic acetylcholine receptor,mAChR,hM4Di,JHU-37152;JHU37152, 10 mM in DMSO;8-Chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5H-dibenzo[b,e][1,4]diazepine
CAS:2369979-67-7
MF:C19H20ClFN4
MW:358.84
EINECS:
Product Categories:
Mol File:2369979-67-7.mol
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro- Structure
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro- Chemical Properties
Boiling point 492.6±55.0 °C(Predicted)
density 1.34±0.1 g/cm3(Predicted)
storage temp. Store at RT
solubility DMSO|35.88|100|ethanol|35.88|100|
form solid
pka7.63±0.10(Predicted)
color Yellow
Safety Information
MSDS Information
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro- Usage And Synthesis
UsesJHU37152 is a potent and brain-penetrant DREADD agonist, with EC50s of 5nM and 0.5nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37152 exhibits selective [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue[1].
in vivo

JHU37152 (0.1 mg/kg; i.p.) exhibits high DREADD occupancy in mice and rats[1].
JHU37152 (0.01-1 mg/kg; i.p.) selectively inhibits locomotor activity in D1-hM3Dq and D1-hM4Di mice without any significant locomotor effects observed in WT mice[1].

IC 50mAChR3; mAChR4
storageRoom temperature
References[1] Bonaventura J, et, al. High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat Commun. 2019 Oct 11;10(1):4627. DOI:10.1038/s41467-019-12236-z
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro- Preparation Products And Raw materials
Tag:5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-(2369979-67-7) Related Product Information
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro- perlapine 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride Clozapine N-oxide 11-Piperazinyldibenzo[b,e][1,4]diazepine Clemastine fumarate