Benzonitrile, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]-

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Products Intro: Product Name:(R)-Fadrozole
CAS:102676-87-9
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Products Intro: Product Name:(R)-Fadrozole
CAS:102676-87-9
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10mg，more
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Products Intro: Product Name:(R)-Fadrozole
CAS:102676-87-9
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Products Intro: Product Name:Fadrozole Impurity 1
CAS:102676-87-9
Purity:99% HPLC Package:10mg、25mg、50mg、100mg

Benzonitrile, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]- manufacturers

  • (R)-Fadrozole
  • (R)-Fadrozole pictures
  • $1543.00
  • 2026-05-11
  • CAS:102676-87-9
  • Purity:
  • Supply Ability: 10g
Benzonitrile, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]- Basic information
Product Name:Benzonitrile, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]-
Synonyms:Benzonitrile, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]-;(R)-CGS 16949A free base;(R)-Fadrozole;(R) Fadrozole,(R)Fadrozole;(R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile;Fadrozole Impurity 1
CAS:102676-87-9
MF:C14H13N3
MW:223.27
EINECS:
Product Categories:
Mol File:102676-87-9.mol
Benzonitrile, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]- Structure
Benzonitrile, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]- Chemical Properties
Boiling point 481.7±38.0 °C(Predicted)
density 1.20±0.1 g/cm3(Predicted)
form Solid
pka7.16±0.40(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
Benzonitrile, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]- Usage And Synthesis
UsesDexfadrostat ((R)-Fadrozole) is a potent nonsteroidal inhibitor[1]. Dexfadrostat also inhibits human placental aromatase (pIC50 = 6.17) and aldosterone biosynthesis. Dexfadrostat reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.[1][2].
in vivo

Dexfadrostat ((R)-fadrozole; 0.24 and 1.2 mg/kg; daily; oral) and (S)-fadrozole similarly decreases plasma aldosterone levels, whereas urinary aldosterone excretion rate was reduced only by S-fadrozole[2].
Dexfadrostat (0.24 and 1.2 mg/kg; daily; oral) effectively reverses preexistent left ventricular interstitial fibrosis by 50% (vs. 42% for canrenoate), S-fadrozole was devoid of an antifibrotic effect[2].

Animal Model:SHHF rats[2]
Dosage:0.24 and 1.2 mg/kg
Administration:Daily; oral
Result:Decreased plasma aldosterone levels and reversed preexistent left ventricular interstitial fibrosis.
References[1] Furet P, et al. Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds. J Med Chem. 1993;36(10):1393-1400. DOI:10.1021/jm00062a012
[2] Minnaard-Huiban M, et al. Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone. Endocrinology. 2008;149(1):28-31. DOI:10.1210/en.2007-0584
Benzonitrile, 4-[(5R)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]- Preparation Products And Raw materials
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