Methanone, [4-(cyclopropylamino)-1-piperidinyl][6-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-2-methyl-3-pyridinyl]-

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Methanone, [4-(cyclopropylamino)-1-piperidinyl][6-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-2-methyl-3-pyridinyl]- Suppliers list
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Methanone, [4-(cyclopropylamino)-1-piperidinyl][6-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-2-methyl-3-pyridinyl]- Basic information
Product Name:Methanone, [4-(cyclopropylamino)-1-piperidinyl][6-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-2-methyl-3-pyridinyl]-
Synonyms:Methanone, [4-(cyclopropylamino)-1-piperidinyl][6-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-2-methyl-3-pyridinyl]-;Cimpuciclib
CAS:2202767-78-8
MF:C30H35FN8O
MW:542.65
EINECS:
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Mol File:2202767-78-8.mol
Methanone, [4-(cyclopropylamino)-1-piperidinyl][6-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-2-methyl-3-pyridinyl]- Structure
Methanone, [4-(cyclopropylamino)-1-piperidinyl][6-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-2-methyl-3-pyridinyl]- Chemical Properties
Boiling point 777.9±70.0 °C(Predicted)
density 1.39±0.1 g/cm3(Predicted)
pka8.37±0.20(Predicted)
Safety Information
MSDS Information
Methanone, [4-(cyclopropylamino)-1-piperidinyl][6-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-2-methyl-3-pyridinyl]- Usage And Synthesis
UsesCimpuciclib is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity[1].
in vivo

Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) inhibits tumor growth in colo205 tumor-bearing mice[1].
Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) shows slow metabolic rate and maintains high concentration in the plasma[1].

Animal Model:Colo205 tumor-bearing mice[1]
Dosage:50 mg/kg, twice a week
Administration:Oral gavage
Result:Inhibited tumor growth by 93.63%.
Animal Model:Rats, colo205 tumor-bearing mice[1]
Dosage:5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
Administration:Oral administration
Result:Pharmacokinetic profile of Cimpuciclib (example 63).
dose (mg/kg) Cmax (ng/mL) Tmax (h) AUC0-24 (ng/mLh) t1/2 (h)
5 mg/kg (rats)559.7654142.4
50 mg/kg (mice)7960113678214.8
IC 50CDK4: 0.49 nM (IC50); CDK6: 9.56 nM (IC50)
References[1] Liu Shiqiang, et al. Preparation of benzimidazole compound as kinase inhibitor. Patent WO 2018045956.
Methanone, [4-(cyclopropylamino)-1-piperidinyl][6-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-2-methyl-3-pyridinyl]- Preparation Products And Raw materials
Tag:Methanone, [4-(cyclopropylamino)-1-piperidinyl][6-[[5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinyl]amino]-2-methyl-3-pyridinyl]-(2202767-78-8) Related Product Information
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