- 2-methoxy-5-picoline
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- $0.00 / 100gm
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2026-01-30
- CAS:13472-56-5
- Min. Order: 100gm
- Purity: 99%min
- Supply Ability: 100kgs
- 2-METHOXY-5-PICOLINE
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- $0.00 / 25KG
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2025-12-01
- CAS:13472-56-5
- Min. Order: 1KG
- Purity: 98.0%
- Supply Ability: 10000KGS
- 2-METHOXY-5-PICOLINE
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- $1.10 / 1g
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2025-11-18
- CAS:13472-56-5
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons min
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| | 2-METHOXY-5-PICOLINE Basic information |
| Product Name: | 2-METHOXY-5-PICOLINE | | Synonyms: | 2-METHOXY-5-PICOLINE;2-Methoxy-5-methylpyridine;Pyridine,2-Methoxy-5-Methyl-;6-Methoxy-3-picoline;2-METHOXY-5-PICOLINE ISO 9001：2015 REACH | | CAS: | 13472-56-5 | | MF: | C7H9NO | | MW: | 123.15 | | EINECS: | | | Product Categories: | Pyridine | | Mol File: | 13472-56-5.mol |  |
| | 2-METHOXY-5-PICOLINE Chemical Properties |
| Boiling point | 165°C(lit.) | | density | 1.001±0.06 g/cm3(Predicted) | | refractive index | 1.5000 to 1.5040 | | storage temp. | Sealed in dry,Room Temperature | | form | clear liquid | | pka | 3.69±0.10(Predicted) | | color | Colorless to Light yellow | | λmax | 279nm(CH3CN)(lit.) |
| | 2-METHOXY-5-PICOLINE Usage And Synthesis |
| Chemical Properties | colorless liquid | | Synthesis | Example 5: General procedure for the preparation of 2-methoxy-5-methylpyridine from 2-bromo-5-methylpyridine
1. 250 g (1.45 mol) of 2-bromo-5-methylpyridine, 2.1 g (1 mol%) of copper(I) bromide (CuBr), 14.5 g (2 mol%) of poly(ethylene glycol) dimethyl ether 500, and 457 g of 30% sodium methanol solution (precursor concentration of 14.5%) were added to a reactor.
2. the reaction mixture was heated to 90 °C and the progress of the reaction was monitored by GC until the conversion was >98.5% (reaction time totaled 17 hours).
3. upon completion of the reaction, the reaction mixture was quenched by slowly adding 750 g of water.
4. The pH of the mixture was adjusted to 9 by dropwise addition of hydrochloric acid, followed by filtration through decalite to remove insoluble material.
5. The aqueous phase was extracted twice with methyl tert-butyl ether (MTBE) (350 g each).
6. The organic phases were combined and subjected to vacuum fractionation to afford 162.8 g (1.32 mol, 91% yield) of 2-methoxy-5-methylpyridine with a GC purity of >98% (a/a). | | References | [1] Patent: US2008/71084, 2008, A1. Location in patent: Page/Page column 4 |
| | 2-METHOXY-5-PICOLINE Preparation Products And Raw materials |
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