3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine manufacturers
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| | 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Basic information |
| | 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Chemical Properties |
| Boiling point | 448.8±45.0 °C(Predicted) | | density | 1.182±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 9.35±0.29(Predicted) |
| | 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Usage And Synthesis |
| Chemical Properties | Grey to purple powder | | Synthesis | Tert-butyl 4-(3-nitropyridin-2-yl)piperazine-1-carboxylate (350 mg, 1.14 mmol) was used as a raw material and mixed with Pd/C (60.4 mg, 10% w/w, 0.0568 mmol) and methanol (6 mL). The hydrogenation reaction was carried out at room temperature using a hydrogen balloon to provide a hydrogen atmosphere. The reaction mixture was stirred for 2 h and then filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (eluent ratio hexane/EtOAc/CH2Cl2 = 1:1:1) to afford the target product tert-butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate (246 mg, 78% yield) as a white powder. Mass spectrometry (EI) analysis resulted in a molecular ion peak (MH+) of 279.2 for C14H22N4O2. | | References | [1] Journal of Medicinal Chemistry, 1994, vol. 37, # 7, p. 999 - 1014
[2] Patent: WO2012/61337, 2012, A1. Location in patent: Page/Page column 45
[3] Patent: WO2008/112440, 2008, A1. Location in patent: Page/Page column 38-39
[4] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 11, p. 1406 - 1411
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2011, vol. 54, # 7, p. 363 - 366 |
| | 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Preparation Products And Raw materials |
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