- Thiazole
-
- $0.00 / 25KG
-
2025-12-01
- CAS:288-47-1
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 10000KGS
- Thiazole
-
- $0.00 / 1kg
-
2025-04-04
- CAS:288-47-1
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
- Thiazole
-
- $0.00 / 1kg
-
2024-07-15
- CAS:288-47-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10ton
Related articles - Synthesis of Thiazole
- Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type ....
- Jan 24，2022
|
| | Thiazole Basic information |
| | Thiazole Chemical Properties |
| Melting point | -33°C | | Boiling point | 117-118 °C (lit.) | | density | 1.2 g/mL at 25 °C (lit.) | | FEMA | 3615 | THIAZOLE | | refractive index | n20/D 1.538(lit.) | | Fp | 72 °F | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | pka | 2.44(at 20℃) | | form | Liquid | | color | Clear colorless to yellow | | Specific Gravity | 1.200 | | Odor | at 0.10 % in propylene glycol. pyridine nutty meaty | | Odor Type | fishy | | biological source | synthetic | | Water Solubility | slightly soluble | | Sensitive | Air & Light Sensitive | | Merck | 14,9307 | | JECFA Number | 1032 | | BRN | 103852 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChI | 1S/C3H3NS/c1-2-5-3-4-1/h1-3H | | InChIKey | FZWLAAWBMGSTSO-UHFFFAOYSA-N | | SMILES | c1cscn1 | | LogP | 0.44 | | CAS DataBase Reference | 288-47-1(CAS DataBase Reference) | | NIST Chemistry Reference | Thiazole(288-47-1) | | EPA Substance Registry System | Thiazole (288-47-1) |
| Hazard Codes | Xn,F | | Risk Statements | 10-22-37/38-41 | | Safety Statements | 16-26-39 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | RTECS | XJ1290000 | | F | 8-10-23 | | TSCA | TSCA listed | | HazardClass | 3 | | PackingGroup | II | | HS Code | 29341000 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 4 Oral
Flam. Liq. 2 |
| | Thiazole Usage And Synthesis |
| Chemical Properties | colourless or pale yellow liquid with a disgusting smell | | Chemical Properties | Thiazole has a green, sweet, nutty, tomato note. | | Occurrence | Reported found in roasted chicken, chicken fat, boiled and cooked beef, grilled and roasted beef, pork liver, beer, cognac and other types of grape brandy, rum, coffee, roasted barley, roasted filbert, roasted peanut, soybean, popcorn, oat products, rice bran, buckwheat, malt, wort, dried bonito, crab, crayfish, Chinese quince and other natural sources. | | Uses | Thiazoles were used to create novel recognition motifs for interaction with divalent and trivalent metal ions in siderophores or antibiotics. | | Uses | Thiazole is used as a flavoring agent and in the preparation of dyes and rubber accelerators. It serves as a component of the vitamin thiamine (B1). It acts as a protected formyl group used in natural product synthesis. It reacts with alkyl lithium and Grignards reagent to prepare organometallic complexes. It is involved in the electrophilic aromatic substitution and nucleophilic aromatic substitution at C-5 and C-2 positions respectively. Further, it undergoes alkylation reaction to get thiazolium cation, which is used as a catalyst in the Stetter reaction and the Benzoin condensation. In addition to this, it is involved in the preparation of alagebrium. | | Uses | Organic synthesis of fungicides, dyes, and rubber
accelerators. | | Definition | A colorless volatile liquid, a beterocyclic compound with a five-membered ring
containing three carbon atoms, one nitrogen atom, and one sulfur atom. It resembles PYRIDINE in its reactions. | | Definition | thiazole: A heterocyclic compound containing a five-membered ringwith sulphur and nitrogen heteroatoms, C3SNH3. A range of thiazoledyes are manufactured containingthis ring system. | | Application | The generation of thiazole derivatives by means of condensation of α-haloketones and thioamidesis referred to as the Hantzsch thiazole synthesis. This reaction takes place due to the strong nucleophilicity of the sulfur atom in thioamides or thioureas, and gives fantabulous yields for simple thiazoles but low yields for some substituted thiazoles, as of dehalogenation. It is a multistep reaction, and the intermediates have been isolated at low temperatures. This reaction has been changed to reduce the epimerization upon the formation of thiazole. Additionally, α-tosyloxy ketones have been used to replace α-haloketones for such reactions. It has wide application in the preparation of thiazole derivatives.
| | Aroma threshold values | Detection: 3.1 ppm | | General Description | Colorless or pale yellow liquid with a foul odor. | | Air & Water Reactions | Slightly water soluble. | | Reactivity Profile | Thioisocyanates, such as Thiazole, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. |
| | Thiazole Preparation Products And Raw materials |
|