Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro-

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Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro- Suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro- Basic information
Product Name:Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro-
Synonyms:Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro-;5-HT2CR agonist 1
CAS:1216074-15-5
MF:C13H14ClNO
MW:235.71
EINECS:
Product Categories:
Mol File:1216074-15-5.mol
Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro- Structure
Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro- Chemical Properties
Boiling point 367.9±42.0 °C(Predicted)
density 1.26±0.1 g/cm3(Predicted)
pka9.59±0.20(Predicted)
Safety Information
MSDS Information
Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro- Usage And Synthesis
Uses5-HT2CR agonist 1 (compound 8), a 7-chloro analogue, is a selective 5-HT2CR partial agonist (Emax=71.09%) with an EC50 value of 121.5 nM and no observed activity toward 5-HT2AR or 5-HT2BR. 5-HT2CR agonist 1 exhibits no recruitment activity for β-arrestin and shows low inhibition of hERG at 10 μM[1].
IC 505-HT2C Receptor: 121.5 nM (EC50)
References[1] Guangqian Jiang, et al Identification of Spiro[chromene-2,4′-piperidine]s as Potent, Selective, and Gq-Biased 5-HT2C Receptor Partial Agonists. ACS Med. Chem. Lett. December 18, 2023.
Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro- Preparation Products And Raw materials
Tag:Spiro[2H-1-benzopyran-2,4'-piperidine], 7-chloro-(1216074-15-5) Related Product Information
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