| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Zorubicin
CAS:54083-22-6
Package:25mg/RMB 32600;100mg/RMB 57500;50mg/RMB 43800
|
| Company Name: |
Wonda Science
|
| Tel: |
+1 (514) 581-6866 |
| Email: |
wonda@wondascience.com |
| Products Intro: |
|
|
| | Zorubicin Basic information |
| Product Name: | Zorubicin | | Synonyms: | N-[1-[(2S,4S)-4-(4-Amino-5-hydroxy-6-methyloxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethylideneamino]benzamide;Benzoic acid 2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxonaphthacen-2-yl]ethylidene] hydrazide;Daunomycin benzoylhydrazone;N-[(E)-1-[(2S,4S)-4-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethylideneamino]benzamide;Rubidazone;ZORUBICIN;Benzoic acid, 1-(2S,4S)-4-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenylethylidenehydrazide;RUBIDAZON | | CAS: | 54083-22-6 | | MF: | C34H35N3O10 | | MW: | 645.66 | | EINECS: | | | Product Categories: | | | Mol File: | 54083-22-6.mol |  |
| | Zorubicin Chemical Properties |
| Boiling point | 675.08°C (rough estimate) | | density | 1.2920 (rough estimate) | | refractive index | 1.7800 (estimate) |
| | Zorubicin Usage And Synthesis |
| Originator | Zorubicin
Hydrochloride,ZYF Pharm
Chemical | | Uses | Antineoplastic. | | Manufacturing Process | 9.024 g daunorubicin-hydrochloride (its preparation and physicochemical
properties have been described in British Patent Specification No 985 598)
was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162
g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained
precipitate was filtered off, washed with 100 ml of ethanol and dried in
vacuum at 20°C. It was dissolved in water and small quantity of insoluble
product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6-
trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-
trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide
dihydrochloride (zorubicin) was obtained as red-orange crystalline powder;
[α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form
of different non-toxic salts such as benzoates, fumarates, maleates, tartrates
and so on. The best among these compounds proves to be daunorubicin
benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No.
1,578,722 published in 1967, Class CO7d). | | Therapeutic Function | Antineoplastic, Antileukemic | | in vivo | Zorubicin (12-18 mg/kg; i.p. 48 h after tumour cells injection) affects leukaemic colony forming units[1].
Zorubicin (0.75-6.0 mg/kg; i.v.) increases plasma histamine concentrations and produces immediate hypotension in anesthetized beagle dogs[3]. | Animal Model: | Six- to eight-week-old male DBA2 mice with P388 tumour cells[1] | | Dosage: | 12-18 mg/kg | | Administration: | Intraperitoneal injection ; 12-18 mg/kg; 48 h after tumour cells injection | | Result: | Showed a D1/2 value of 1.6 mg/kg for leukaemic colony forming units.
|
|
| | Zorubicin Preparation Products And Raw materials |
|