奥替尼啶盐酸盐
| 中文名称 | 奥替尼啶盐酸盐 |
|---|---|
| 中文同义词 | 奥替尼啶 奥克太啶(双盐酸盐);奥克太啶盐酸盐;奥替尼啶盐酸盐;奥替尼啶 二盐酸盐;奥替尼啶杂质;奥替尼啶,奥克太啶;奥替尼定盐酸盐;盐酸奥替尼啶 |
| 英文名称 | Octenidine dihydrochloride |
| 英文同义词 | N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis(1-octanamine) dihydrochloride;N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride;Octenidine hydrochloride;OCTENIDINE DIHYDROCHLORIDE;N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-1-octanaMine Hydrochloride;N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylaMMoniuM) dichloride;1-OctanaMine,N,N'-(1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-, hydrochloride (1:2);ocenidine dihydrochloride |
| CAS号 | 70775-75-6 |
| 分子式 | C36H64Cl2N4 |
| 分子量 | 623.82616 |
| EINECS号 | 274-861-8 |
| 相关类别 | 原料药;医药原料;原料药;化妆品原料;抗菌;新型抗菌;医药原料药;合成;医药 抗菌剂;医用原料;医药化工原料;化工原料;化工中间体;原料;其他原料;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;化学试剂;化工品 |
| Mol文件 | 70775-75-6.mol |
| 结构式 |  |
奥替尼啶盐酸盐 性质
| 熔点 | 215-217℃ |
|---|---|
| 密度 | 1.046[at 20℃] |
| 蒸气压 | 0Pa at 25℃ |
| 储存条件 | Keep in dark place,Inert atmosphere,Room temperature |
| 溶解度 | 溶于二甲基亚砜和甲醇。 |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 水溶解性 | 14.2g/L at 20℃ |
| Merck | 14,6754 |
| 稳定性 | 吸湿性 |
| 化妆品成分功效 | ANTIMICROBIAL |
| InChIKey | SMGTYJPMKXNQFY-UHFFFAOYSA-N |
| SMILES | [N+]1(CCCCCCCCCC[N+]2C=CC(NCCCCCCCC)=CC=2)=CC=C(NCCCCCCCC)C=C1.[Cl-].[Cl-] |
| LogP | 1.5 at 23℃ |
Octenidine concentrations of less than1.5 μM (0.94 μg/mL) causes a greater than 99% reduction of tested microbial population within 15 min. Staphylococcus epidermidis is the most susceptible of the test organisms, and E. coli and C. albicans are the least susceptible.
The antimicrobial activity of octenidine hydrochloride (OCT) is maintained when applied to the skin of the hands and feet of cynomolgus monkeys. Aqueous octenidine, at a concentration of 0.2 to 1.6% reduces resident microflora populations from 90 to 99.98%. A significant reduction in plaque score is observed on the buccal tooth surfaces after daily topical application of 1% solutions of octenidine and chlorhexidine for 7 d; octenidine is more effective than chlorhexidine.
2162-98-3
64690-19-3
70775-75-6
以1,10-二氯癸烷和4-(辛基氨基)吡啶为原料，合成N,N'-[1,10-亚癸基二-1(4H)-吡啶-4-亚基]双(1-辛胺)二盐酸盐的一般步骤如下：将6.18 g的4-(辛基氨基)吡啶碱和3.15 g的1,10-二氯癸烷混合，缓慢加热至120℃，反应放热至180℃，期间通过薄层色谱（TLC）监测反应进程。反应完成后，加入25 mL二甲基甲酰胺（DMF），加热使混合物完全溶解。随后，将混合物冷却至0℃以促进晶体析出，过滤收集晶体，并在60℃下减压干燥。通过上述步骤，获得7.3 g的N,N'-[1,10-亚癸基二-1(4H)-吡啶-4-亚基]双(1-辛胺)二盐酸盐，产率为39.0%，熔点为215至217℃。
参考文献：
[1] Patent: KR2017/13425, 2017, A. Location in patent: Paragraph 0105; 0106
[2] Patent: US2001/16660, 2001, A1
[3] Patent: US2001/16660, 2001, A1
安全信息
| 海关编码 | 2933399990 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-B2170A | 奥替尼啶盐酸盐 Octenidine dihydrochloride | 70775-75-6 | 200mg | 500元 |
| 2025/12/22 | HY-B2170A | 奥替尼啶盐酸盐 Octenidine dihydrochloride | 70775-75-6 | 10mM * 1mLin Water | 550元 |