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[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride

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Company Name: Alchem Pharmtech,Inc.
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Products Intro: Product Name:(3R)-3-(((1S)-1-Hydroxy-1-phenylpropan-2-yl)amino)-3-methoxy-1-phenylpropan-1-one hydrochloride
CAS:16777-42-7
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-35736
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Products Intro: Product Name:[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride
CAS:16777-42-7
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Products Intro: Product Name:Oxyfedrine L-form HCl
CAS:16777-42-7
Purity:98.66% Package:1mg;98USD|5mg;198USD|10mg;347USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shaanxi Dideu Medichem Co. Ltd
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Products Intro: Product Name:[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride USP/EP/BP
CAS:16777-42-7
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: Alfa Chemistry
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Products Intro: Product Name:Oxyfedrine hydrochloride
CAS:16777-42-7
Purity:97%

[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride manufacturers
[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Basic information
Product Name:[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride
Synonyms:(3R)-3-(((1S)-1-Hydroxy-1-phenylpropan-2-yl)amino)-3-methoxy-1-phenylpropan-1-one hydrochloride;[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride;OXYFEDRINE HCL;OXYFEDRINEHYROCHLORIDE;L-OXYFEDRINE HCL;D 563;FDA 1576;Ildamen
CAS:16777-42-7
MF:C19H23NO3.ClH
MW:349.85
EINECS:2408281
Product Categories:
Mol File:16777-42-7.mol
[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Structure
[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Chemical Properties
Melting point 192-194℃
form Solid
color White to off-white
Safety Information
ToxicityLD50 in mice (mg/kg): 29 i.v. (Hueller)
MSDS Information
[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Usage And Synthesis
OriginatorIldamen,Homburg,W. Germany ,1966
UsesOxyfedrine hydrochloride, a vasodilator, is an orally active β-adrenoreceptor agonist. Oxyfedrine decreases the tonicity of coronary vessels. Oxyfedrine hydrochloride can be used in the research of cardiovascular disease[1][2].
Manufacturing Process45 grams of m-methoxy acetophenone, 8 grams of paraformaldehyde and 30.2 grams of 1 norephedrine were mixed with about 135 cc of isopropanol HCl solution to provide a pH of 4 and the mixture refluxed for 4 hours. The reaction mixture was cooled and the crystals filtered off on a suction filter. 3[1-phenyl-1-hydroxypropyl-(2)-amino]-1-(m-methoxyphenyl)-propanone-(1) HCl was obtained which after recrystallization from methanol had a MP of 190° to 193°C.
Therapeutic FunctionCoronary vasodilator
in vivo

Oxyfedrine (14 mg/kg, p.o., for 3-4 weeks) shows anti-anginal action in cats[2].
Oxyfedrine (10 mg/kg, i.p., HCT116 cell xenograft mice) suppresses tumor growth when combined with sulfasalazine (SSZ, 350 mg/kg, i.p.)[1].
Oxyfedrine (1 mg/kg, i.v.) decreases the arterial and venous blood high blood viscosity (HBV) in ice water stress rats[3].

References[1] Otsuki Y, et al. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy. Cancer Sci. 2020 Jan;111(1):127-136. DOI:10.1111/cas.14224
[2] Parratt JR. The haemodynamic effects of prolonged oral administration of oxyfedrine, a partial agonist at beta-adrenoceptors: comparison with propranolol. Br J Pharmacol. 1974 May;51(1):5-13. DOI:10.1111/j.1476-5381.1974.tb09625.x
[3] Yu J, et al. [Effects of oxyfedrine on high blood viscosity and myocardial necrosis induced by epinephrine and ice water stress in rats]. Zhongguo Yao Li Xue Bao. 1993 Jul;14(4):364-6. PMID:8249637
[4] Mackenzie JE, et al. Effects of oxyfedrine on isolated portal vein and other smooth muscles. Br J Pharmacol. 1973 Apr;47(4):827-37. DOI:10.1111/j.1476-5381.1973.tb08210.x
[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Preparation Products And Raw materials
Raw materialsL-(-)-Ephedrine-->3-Methoxyacetophenone-->Paraformaldehyde
Tag:[R-(R*,S*)]-3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride(16777-42-7) Related Product Information
Olopatadine hydrochloride Oxyfedrine Methoxypropiophenone 3-[(2-hydroxy-1-methyl-2-phenylethyl)amino]-3'-methoxypropiophenone hydrochloride Metoprolol Phosphorylcholine