- AC-L-Thz-OH
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- $0.00/ kg
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2026-02-02
- CAS:54323-50-1
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
- N-Acetyl-L-thioproline
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- $50.00 / 1kg
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2025-06-20
- CAS:54323-50-1
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 10000
- N-Acetyl-L-thioproline
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- $10.50 / 1KG
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2025-05-26
- CAS:54323-50-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 ton
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| | N-Acetyl-L-thioproline Basic information |
| | N-Acetyl-L-thioproline Chemical Properties |
| Melting point | 143-145℃ | | Boiling point | 439℃/760mm | | density | 1.46 | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 3.27±0.20(Predicted) | | color | White | | InChI | InChI=1S/C6H9NO3S/c1-4(8)7-3-11-2-5(7)6(9)10/h5H,2-3H2,1H3,(H,9,10)/t5-/m0/s1 | | InChIKey | WXTBYSIPOKXCPM-YFKPBYRVSA-N | | SMILES | S1C[C@@H](C(O)=O)N(C(C)=O)C1 |
| | N-Acetyl-L-thioproline Usage And Synthesis |
| Chemical Properties | off-white to white powder | | Uses | A cysteine derivative as potential antitumor agent | | Synthesis | GENERAL STEPS: L-thioproline (0.11 mol) and potassium chloride solution (100 mL) were added to the reaction vessel. The stirring speed was controlled at 150 rpm. the reaction mixture was heated to 85°C. A solution of 85% 2-thienylacetonitrile (50 mL) was slowly added dropwise with a controlled drip time of 40 min. The stirring rate was maintained and the reaction was continued for 120 minutes. Upon completion of the reaction, a reduced pressure distillation (2.3 kPa) was performed to separate the solid product. To the resulting solid, 90% p-xylene (80 mL) was added and heated to completely dissolve the solid. Decolorization was performed by adding decolorizing molecular sieves, maintaining the solution temperature at 15°C for 35 min. The solid impurities were removed by filtration and dehydrated using phosphorus pentoxide to give the final white N-acetyl-L-thioproline (1) (17.13 g, 89% yield). | | References | [1] Patent: CN105541749, 2016, A. Location in patent: Paragraph 0014; 0015 |
| | N-Acetyl-L-thioproline Preparation Products And Raw materials |
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