| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Email: |
inquiries@lgmpharma.com |
| Products Intro: |
Product Name:Ditazole
CAS:18471-20-0
Purity:Typically NLT 98%
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:Ditazole
CAS:18471-20-0
Purity:NULL Package:10mg;20mg;2mg;5mg Remarks:NULL
|
|
| | ditazole Basic information |
| Product Name: | ditazole | | Synonyms: | 2,2'-[(4,5-Diphenyl-2-oxazolyl)imino]bisethanol;Agerophas;Apt-574;Diethamphenazole;S-222;ditazole;ditazol;2-[(4,5-diphenyl-1,3-oxazol-2-yl)-(2-hydroxyethyl)amino]ethanol | | CAS: | 18471-20-0 | | MF: | C19H20N2O3 | | MW: | 324.37 | | EINECS: | 242-353-5 | | Product Categories: | | | Mol File: | 18471-20-0.mol |  |
| | ditazole Chemical Properties |
| Melting point | 100-101°C | | Boiling point | 505.5±60.0 °C(Predicted) | | density | 1.237±0.06 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 14.08±0.10(Predicted) | | form | Solid | | color | White to Off-White |
| | ditazole Usage And Synthesis |
| Originator | Ageroplas,Serona,Italy,1973 | | Uses | Ditazole is a weak anti-inflammatory drug and a novel inhibitor of platelet aggregation. | | Definition | ChEBI: Ditazole is a member of 1,3-oxazoles. | | Manufacturing Process | A solution of 5.1 grams 2-chloro-4,5-diphenyl-oxazole, 6.3 grams
diethanolamine and 50 ml absolute ethanol was refluxed for 4 hours. The
solvent was stripped at 1 mm and the oily residue was added at 60°C to 100
ml 50% ethanol; by cooling the hydro-alcoholic solution, 4.5 grams of 2-bis(β-
hydroxyethyl)amino-4,5-diphenyl-oxazole was obtained (yield, 69.5%). The
product crystallized from ethyl ether + petroleum ether, with a MP of 96 to
98°C. | | Therapeutic Function | Antiinflammatory | | Trade name | Ageroplas (Lepori, Spain;
Serono, Italy), Fendazol (Lepori, Portugal). | | Mechanism of action | Ditazole is an anti-inflammatory analgesic
agent that is of interest primarily for its ability to inhibit platelet aggregation. For example,
it normalizes the enhanced platelet activity in
cerebrovascular patients suffering transient ischemic attacks. | | Synthesis | ditazole is prepared by heating 2-
chloro-4,5-diphenyloxazole and diethanolamine
in ethanol.
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| | ditazole Preparation Products And Raw materials |
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