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| | MS 154N Basic information |
| Product Name: | MS 154N | | Synonyms: | MS 154N;1-Piperazinepropanamide, 4-[3-[[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]propyl]-N-[8-[[2,3-dihydro-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1,3-dioxo-1H-isoindol-4-yl]oxy]octyl]- | | CAS: | 2675490-97-6 | | MF: | C47H56ClFN8O8 | | MW: | 915.45 | | EINECS: | | | Product Categories: | | | Mol File: | 2675490-97-6.mol |  |
| | MS 154N Chemical Properties |
| Boiling point | 1038.552±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.316±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 16.258±0.46(predicted) | | form | Solid | | color | White to off-white |
| | MS 154N Usage And Synthesis |
| Uses | MS154N (compound 28) is the negative control of MS39 (HY-157581). MS154N is composed of PROTAC target protein ligand EGFR ligand-11 (HY-168305) (red part), E3 ligase ligand 4-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione (HY-W441376) (blue part) and PROTAC Linker 8-Iodooctan-1-amine (HY-168306) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is Me-Thalidomide-O-C8-NH2 (HY-168307)[1]. | | References | [1] Cheng M, et al. Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders. J Med Chem. 2020 Feb 13;63(3):1216-1232. DOI:10.1021/acs.jmedchem.9b01566 |
| | MS 154N Preparation Products And Raw materials |
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